Khalid Al-Rubeaan1, Shaik S Nawaz2, Amira M Youssef3, Mohammed Al Ghonaim4, Khalid Siddiqui2. 1. Department of Medicine, University Diabetes Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia. 2. Biochemistry Department, Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi Arabia. 3. Biochemistry Department, Registry Department, University Diabetes Center, King Saud University, Riyadh, Saudi Arabia. 4. College of Medicine, King Khalid Universe Hospital, King Saud University, Riyadh, Saudi Arabia.
Abstract
Aim: To investigate the pathophysiological role of different biomarkers in diabetic kidney disease (DKD) among normoalbuminuric patients with a low-estimated glomerular filtration rate (eGFR). Methods: In this cross-sectional study of 200 normoalbuminuric Type 2 diabetes patients, 28 patients (14%) had a low eGFR. Results: The IL-18, VCAM-1 and P-selectin levels were significantly higher at a low eGFR. On analyzing the area under the receiver operating characteristic curve, these biomarkers had significant diagnostic value and have important pathophysiological role in the progression of DKD. Conclusion: Among normoalbuminuric Type 2 diabetes patients, IL-18, VCAM-1 and P-selectin may play a significant role in the prediction of early DKD. Further prospective studies need to be conducted to confirm this observation.
Aim: To investigate the pathophysiological role of different biomarkers in diabetic kidney disease (DKD) among normoalbuminuric patients with a low-estimated glomerular filtration rate (eGFR). Methods: In this cross-sectional study of 200 normoalbuminuric Type 2 diabetespatients, 28 patients (14%) had a low eGFR. Results: The IL-18, VCAM-1 and P-selectin levels were significantly higher at a low eGFR. On analyzing the area under the receiver operating characteristic curve, these biomarkers had significant diagnostic value and have important pathophysiological role in the progression of DKD. Conclusion: Among normoalbuminuric Type 2 diabetespatients, IL-18, VCAM-1 and P-selectin may play a significant role in the prediction of early DKD. Further prospective studies need to be conducted to confirm this observation.
Entities:
Keywords:
IL-18; P-selectin; SAUDI-DKD; Type 2 diabetes; VCAM-1; YKL-40; diabetic kidney disease; diabetic retinopathy; low eGFR; pathophysiological role
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