| Literature DB >> 31168816 |
Rory K Morgan1, Garret R Anderson2, Demet Araç3, Gabriela Aust4, Nariman Balenga5,6, Antony Boucard7, James P Bridges8,9, Felix B Engel10, Caroline J Formstone11,12, Maike D Glitsch13, Ryan S Gray14, Randy A Hall15, Cheng-Chih Hsiao16, Hee-Yong Kim17, Alexander B Knierim18, Deva Krupakar Kusuluri19, Katherine Leon3, Ines Liebscher18, Xianhua Piao20, Simone Prömel18, Nicole Scholz21, Swati Srivastava10, Doreen Thor18, Kimberley F Tolias22, Yuri A Ushkaryov23, Mario Vallon24, Erwin G Van Meir25, Benoit Vanhollebeke26,27, Uwe Wolfrum19, Kevin M Wright1, Kelly R Monk1, Amit Mogha1.
Abstract
The adhesion class of G protein-coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane (7TM) domain via a GPCR-autoproteolysis inducing (GAIN) domain containing a GPCR proteolytic site (GPS). Most aGPCRs undergo autoproteolysis at the GPS motif, but the cleaved fragments stay closely associated, with the N-terminal fragment (NTF) bound to the 7TM of the C-terminal fragment (CTF). The NTFs of most aGPCRs contain domains known to be involved in cell-cell adhesion, while the CTFs are involved in classical G protein signaling, as well as other intracellular signaling. In this workshop report, we review the most recent findings on the biology, signaling mechanisms, and physiological functions of aGPCRs.Entities:
Keywords: adhesion G protein-coupled receptor; cancer; development; immunology; mechanosensation; neurobiology; signal transduction; structural biology
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Year: 2019 PMID： 31168816 DOI： 10.1111/nyas.14094
Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691