Literature DB >> 31168541

Clostrindolin is an antimycobacterial pyrone alkaloid from Clostridium beijerinckii.

Sebastian Schieferdecker1, Gulimila Shabuer, Uwe Knuepfer, Christian Hertweck.   

Abstract

Anaerobic bacteria represent an underexplored source of bioactive natural products with unusual structural features. Here we report the isolation and structure elucidation of an antimycobacterial natural product, clostroindolin, produced by Clostridium beijerinckii. Furthermore, we provide first insights into structure activity relationships, which might guide the development of novel antibiotics against mycobacteria.

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Year:  2019        PMID： 31168541     DOI： 10.1039/c9ob00968j

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  5 in total

1.  Oak-Associated Negativicute Equipped with Ancestral Aromatic Polyketide Synthase Produces Antimycobacterial Dendrubins.

Authors:  Keishi Ishida; Gulimila Shabuer; Sebastian Schieferdecker; Sacha J Pidot; Timothy P Stinear; Uwe Knuepfer; Michael Cyrulies; Christian Hertweck
Journal:  Chemistry       Date:  2020-09-17       Impact factor: 5.236

2.  Antimicrobial Activity of Soil Clostridium Enriched Conditioned Media Against Bacillus mycoides, Bacillus cereus, and Pseudomonas aeruginosa.

Authors:  Amila Srilal Nawarathna Weligala Pahalagedara; Steve Flint; Jon Palmer; Arvind Subbaraj; Gale Brightwell; Tanushree Barua Gupta
Journal:  Front Microbiol       Date:  2020-12-04       Impact factor: 5.640

3.  Insights into the bacterial community composition of farmed Caulerpa lentillifera: A comparison between contrasting health states.

Authors:  Germán A Kopprio; Nguyen D Luyen; Le Huu Cuong; Tran Mai Duc; Anna Fricke; Andreas Kunzmann; Le Mai Huong; Astrid Gärdes
Journal:  Microbiologyopen       Date:  2021-11-25       Impact factor: 3.904

4.  Induced Production, Synthesis, and Immunomodulatory Action of Clostrisulfone, a Diarylsulfone from Clostridium acetobutylicum.

Authors:  Toni Neuwirth; Anne-Catrin Letzel; Cedric Tank; Keishi Ishida; Michael Cyrulies; Lisa Schmölz; Stefan Lorkowski; Christian Hertweck
Journal:  Chemistry       Date:  2020-11-03       Impact factor: 5.236

5.  Geographic pattern of antibiotic resistance genes in the metagenomes of the giant panda.

Authors:  Ting Hu; Qinlong Dai; Hua Chen; Zheng Zhang; Qiang Dai; Xiaodong Gu; Xuyu Yang; Zhisong Yang; Lifeng Zhu
Journal:  Microb Biotechnol       Date:  2020-08-18       Impact factor: 5.813
  5 in total

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