Daniela Rohde1, Eva Gaynor2, Margaret Large3, Lisa Mellon1, Patricia Hall3, Linda Brewer4, Kathleen Bennett1, David Williams4, Eamon Dolan5, Elizabeth Callaly6, Anne Hickey1. 1. 1 Population Health Sciences, RCSI, Dublin, Ireland. 2. 2 Department of Medicine, RCSI, Dublin, Ireland. 3. 3 Clinical Research Centre, Beaumont Hospital, Dublin, Ireland. 4. 4 Geriatric and Stroke Medicine, RCSI and Beaumont Hospital, Dublin, Ireland. 5. 5 Geriatric Medicine, Connolly Hospital Blanchardstown, Dublin, Ireland. 6. 6 Geriatric Medicine, Mater Misericordiae University Hospital, Dublin, Ireland.
Abstract
AIM: To explore the impact of cognitive impairment poststroke on outcomes at 5 years. METHODS: Five-year follow-up of the Action on Secondary Prevention Interventions and Rehabilitation in Stroke (ASPIRE-S) prospective cohort. Two hundred twenty-six ischemic stroke survivors completed Montreal Cognitive Assessments at 6 months poststroke. Outcomes at 5 years included independence in activities of daily living, receipt of informal care, quality of life, and depressive symptoms. Data were analyzed using logistic and linear regression models. Adjusted odds ratios (ORs; 95% confidence interval [CI]) and β coefficients (95% CI) are reported. RESULTS: One hundred one stroke survivors were followed up at 5 years. Cognitive impairment at 6 months was independently associated with worse quality of life (B [95% CI]: -0.595 [-0.943 to -0.248]), lower levels of independence (B [95% CI]: -3.605 [-5.705 to -1.505]), increased likelihood of receiving informal care (OR [95% CI]: 6.41 [1.50-27.32]), and increased likelihood of depressive symptoms (OR [95% CI]: 4.60 [1.22-17.40]). Conclusion: Cognitive impairment poststroke is associated with a range of worse outcomes. More effective interventions are needed to improve outcomes for this vulnerable group of patients.
AIM: To explore the impact of cognitive impairment poststroke on outcomes at 5 years. METHODS: Five-year follow-up of the Action on Secondary Prevention Interventions and Rehabilitation in Stroke (ASPIRE-S) prospective cohort. Two hundred twenty-six ischemic stroke survivors completed Montreal Cognitive Assessments at 6 months poststroke. Outcomes at 5 years included independence in activities of daily living, receipt of informal care, quality of life, and depressive symptoms. Data were analyzed using logistic and linear regression models. Adjusted odds ratios (ORs; 95% confidence interval [CI]) and β coefficients (95% CI) are reported. RESULTS: One hundred one stroke survivors were followed up at 5 years. Cognitive impairment at 6 months was independently associated with worse quality of life (B [95% CI]: -0.595 [-0.943 to -0.248]), lower levels of independence (B [95% CI]: -3.605 [-5.705 to -1.505]), increased likelihood of receiving informal care (OR [95% CI]: 6.41 [1.50-27.32]), and increased likelihood of depressive symptoms (OR [95% CI]: 4.60 [1.22-17.40]). Conclusion:Cognitive impairment poststroke is associated with a range of worse outcomes. More effective interventions are needed to improve outcomes for this vulnerable group of patients.
Entities:
Keywords:
activities of daily living; cerebrovascular disorders; cognitive impairment; depression; independence; quality of life; stroke
Authors: Daniela Pinter; Simon Fandler-Höfler; Viktoria Fruhwirth; Lisa Berger; Gerhard Bachmaier; Susanna Horner; Sebastian Eppinger; Markus Kneihsl; Christian Enzinger; Thomas Gattringer Journal: Front Neurol Date: 2022-04-25 Impact factor: 4.086
Authors: Daniela Rohde; Eva Gaynor; Margaret Large; Lisa Mellon; Kathleen Bennett; David J Williams; Linda Brewer; Patricia Hall; Elizabeth Callaly; Eamon Dolan; Anne Hickey Journal: PLoS One Date: 2019-10-17 Impact factor: 3.240