Qilong Zhang1, Hang Li1,2, Keming Zhang2,3, Amir Arastehfar4, Farnaz Daneshnia4, Wenjie Fang2,3, Peijuan He1, Weifeng Kuang1, Guoqiang Jiang1, Min Chen2,3, Teun Boekhout2,4,5, Shuai Li6, Weiwei Jiang2,3, Wanqing Liao2,3, Weihua Pan2,3. 1. Department of Internal Neurology, Jiangxi Chest Hospital, Jiangxi 330000, PR China. 2. Shanghai Key Laboratory of Molecular Medical Mycology, Shanghai Institute of Mycology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, PR China. 3. Department of Dermatology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, PR China. 4. Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands. 5. Institute of Biodiversity & Ecosystem Dynamics, University of Amsterdam, Amsterdam 1012 WX, The Netherlands. 6. Department of Clinical Laboratory, Yan'an People's Hospital, Shanxi 716000, PR China.
Abstract
Aim: This study aims to evaluate lumbar drainage (LD) for controlling refractory intracranial hypertension among non-HIV cryptococcal meningitis patients. Patients & methods: A case-control study was designed to compare LD (case) with repeated lumbar puncture (control). Results: Both LD and repeated lumbar puncture can efficiently control refractory intracranial hypertension. LD group showed better clinical symptom remission, such as lower rate of headache, vision disorders, signs of meningeal irritation and conscious disturbance, than control group. LD group was reported with higher intracranial pressure reduction (173.75 ± 17.72 mmH2O) than those among control group (113.50 ± 14.94 mmH2O; p < 0.05). Conclusion: LD is an effective and safe alternative to control refractory intracranial hypertension in HIV-negative cryptococcal meningitis patients.
Aim: This study aims to evaluate lumbar drainage (LD) for controlling refractory intracranial hypertension among non-HIV cryptococcal meningitispatients. Patients & methods: A case-control study was designed to compare LD (case) with repeated lumbar puncture (control). Results: Both LD and repeated lumbar puncture can efficiently control refractory intracranial hypertension. LD group showed better clinical symptom remission, such as lower rate of headache, vision disorders, signs of meningeal irritation and conscious disturbance, than control group. LD group was reported with higher intracranial pressure reduction (173.75 ± 17.72 mmH2O) than those among control group (113.50 ± 14.94 mmH2O; p < 0.05). Conclusion:LD is an effective and safe alternative to control refractory intracranial hypertension in HIV-negative cryptococcal meningitispatients.
Authors: Yasir A Chowdhury; Andrew R Stevens; Wai C Soon; Emma Toman; Tonny Veenith; Ramesh Chelvarajah; Antonio Belli; David Davies Journal: Cureus Date: 2022-06-12