Mahdieh Golzarand1, Karamollah Toolabi2, Mehdi Hedayati3, Kamal Azam4, Masoomeh Douraghi5, Kurosh Djafarian6. 1. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, No 44, Hojatdoost St., Naderi St., Keshavarz Blvd, Tehran, Iran. 2. Department of Surgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. tolabika@tums.ac.ir. 3. Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. 5. Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. 6. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, No 44, Hojatdoost St., Naderi St., Keshavarz Blvd, Tehran, Iran. kdjafarian@tums.ac.ir.
Abstract
PURPOSE: Laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) are the most common techniques for treatment of morbid obesity. However, a few studies have compared the energy expenditure and plasma amino acid profile after LRYGB and LSG. The present study was conducted to assess the resting metabolic rate (RMR) and plasma amino acid profile in obese patients who underwent LRYGB and LSG before and 6 months after the surgery in order to compare these changes from baseline between the two procedures. MATERIALS AND METHODS: Forty-three adult obese patients participated in this study (LRYGB = 22 and LSG = 21) and were followed up for 6 months. RMR was measured by indirect calorimetry. The plasma amino acid profile was determined using high-performance liquid chromatography (HPLC). RESULTS: Mean percent excess weight loss (%WL) were 22.8 ± 4.5% and 23.3 ± 5.7% in LRYGB and LSG, respectively. RMR reduced significantly from baseline by - 459 ± 202 kcal/day in LRYGB and - 500 ± 262 kcal/day in LSG. RMR reduced beyond the expected decrease in both procedures. A decreasing trend was observed in the plasma concentration of branched-chain amino acids (BCAA), aromatic amino acids (AAA), and amino acid index (AAI) in both techniques. There was no significant difference in weight, RMR analysis, and amino acid change from baseline between LRYGB and LSG. CONCLUSION: Our results showed that the effects of LRYGB and LSG on RMR and amino acid profile were comparable.
PURPOSE: Laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) are the most common techniques for treatment of morbid obesity. However, a few studies have compared the energy expenditure and plasma amino acid profile after LRYGB and LSG. The present study was conducted to assess the resting metabolic rate (RMR) and plasma amino acid profile in obesepatients who underwent LRYGB and LSG before and 6 months after the surgery in order to compare these changes from baseline between the two procedures. MATERIALS AND METHODS: Forty-three adult obesepatients participated in this study (LRYGB = 22 and LSG = 21) and were followed up for 6 months. RMR was measured by indirect calorimetry. The plasma amino acid profile was determined using high-performance liquid chromatography (HPLC). RESULTS: Mean percent excess weight loss (%WL) were 22.8 ± 4.5% and 23.3 ± 5.7% in LRYGB and LSG, respectively. RMR reduced significantly from baseline by - 459 ± 202 kcal/day in LRYGB and - 500 ± 262 kcal/day in LSG. RMR reduced beyond the expected decrease in both procedures. A decreasing trend was observed in the plasma concentration of branched-chain amino acids (BCAA), aromatic amino acids (AAA), and amino acid index (AAI) in both techniques. There was no significant difference in weight, RMR analysis, and amino acid change from baseline between LRYGB and LSG. CONCLUSION: Our results showed that the effects of LRYGB and LSG on RMR and amino acid profile were comparable.
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