Duygu Hünerli1, Derya Durusu Emek-Savaş2, Berrin Çavuşoğlu3, Berril Dönmez Çolakoğlu4, Emel Ada5, Görsev G Yener6. 1. Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, Izmir 35340, Turkey. 2. Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, Izmir 35340, Turkey; Department of Psychology, Faculty of Letters, Dokuz Eylul University, Izmir 35160, Turkey; Atlantic Fellow for Equity in Brain Health at the Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland. 3. Department of Medical Physics, Institute of Health Sciences, Dokuz Eylul University, Izmir 35340, Turkey. 4. Department of Neurology, Dokuz Eylul University Medical School, Izmir 35340, Turkey. 5. Department of Radiology, Dokuz Eylul University Medical School, Izmir 35340, Turkey. 6. Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, Izmir 35340, Turkey; Department of Neurology, Dokuz Eylul University Medical School, Izmir 35340, Turkey; Brain Dynamics Multidisciplinary Research Center, Dokuz Eylul University, Izmir 35340, Turkey. Electronic address: gorsev.yener@deu.edu.tr.
Abstract
OBJECTIVE: Functional and structural brain alterations of cognitively normal Parkinson's disease (PD-CN) and Parkinson's disease mild cognitive impairment (PD-MCI) patients were investigated using event-related potentials (ERP) P300 and volumetric magnetic resonance imaging (MRI) parameters. METHODS: Twenty three patients with PD-CN, 21 with PD-MCI, and 23 demographically-matched healthy controls were included. EEGs were recorded using a visual oddball task and mean amplitude and peak latency values of P300 were measured. Gray matter volumes (GMV) of thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala and nucleus accumbens were obtained using FMRIB Integrated Registration and Segmentation Tool. Correlations among P300, subcortical GMV and cognitive performances were assessed. RESULTS: PD-CN patients demonstrated reduced P300 amplitudes compared to healthy controls. PD-MCI patients had lower P300 amplitudes than both PD-CN patients and controls and reduced volumes of the putamen compared to controls. Both putamen volumes and P300 amplitudes showed moderate associations with executive functions. CONCLUSIONS: Our findings support that P300 amplitude may be a useful marker for the detection of preclinical changes before the appearance of cognitive and structural deterioration in PD, as shown by decreased frontal P300 amplitudes in PD-CN. The reduction further spread to centro-parietal areas in PD-MCI patients, which was accompanied by lower putamen volumes. SIGNIFICANCE: This study is the first to report on changes in ERP P300 amplitude and subcortical volume in well-matched samples of PD-CN, PD-MCI and healthy controls.
OBJECTIVE: Functional and structural brain alterations of cognitively normal Parkinson's disease (PD-CN) and Parkinson's disease mild cognitive impairment (PD-MCI) patients were investigated using event-related potentials (ERP) P300 and volumetric magnetic resonance imaging (MRI) parameters. METHODS: Twenty three patients with PD-CN, 21 with PD-MCI, and 23 demographically-matched healthy controls were included. EEGs were recorded using a visual oddball task and mean amplitude and peak latency values of P300 were measured. Gray matter volumes (GMV) of thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala and nucleus accumbens were obtained using FMRIB Integrated Registration and Segmentation Tool. Correlations among P300, subcortical GMV and cognitive performances were assessed. RESULTS:PD-CNpatients demonstrated reduced P300 amplitudes compared to healthy controls. PD-MCIpatients had lower P300 amplitudes than both PD-CNpatients and controls and reduced volumes of the putamen compared to controls. Both putamen volumes and P300 amplitudes showed moderate associations with executive functions. CONCLUSIONS: Our findings support that P300 amplitude may be a useful marker for the detection of preclinical changes before the appearance of cognitive and structural deterioration in PD, as shown by decreased frontal P300 amplitudes in PD-CN. The reduction further spread to centro-parietal areas in PD-MCIpatients, which was accompanied by lower putamen volumes. SIGNIFICANCE: This study is the first to report on changes in ERPP300 amplitude and subcortical volume in well-matched samples of PD-CN, PD-MCI and healthy controls.
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Authors: Steven H J Nagtegaal; Szabolcs David; Marielle E P Philippens; Tom J Snijders; Alexander Leemans; Joost J C Verhoeff Journal: Clin Transl Radiat Oncol Date: 2020-11-15
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Authors: Zoya O Serebrovska; Tetiana V Serebrovska; Viktor A Kholin; Lesya V Tumanovska; Angela M Shysh; Denis A Pashevin; Sergii V Goncharov; Dmytro Stroy; Oksana N Grib; Valeriy B Shatylo; Natalia Yu Bachinskaya; Egor Egorov; Lei Xi; Victor E Dosenko Journal: Int J Mol Sci Date: 2019-10-30 Impact factor: 5.923
Authors: Zoya O Serebrovska; Lei Xi; Lesya V Tumanovska; Angela M Shysh; Sergii V Goncharov; Michael Khetsuriani; Taisia O Kozak; Denis A Pashevin; Victor E Dosenko; Sergii V Virko; Viktor A Kholin; Oksana N Grib; Natalie A Utko; Egor Egorov; Anna O Polischuk; Tetiana V Serebrovska Journal: Life (Basel) Date: 2022-03-16