Nelleke P M Brouwer1, Thea C Heil2, Marcel G M Olde Rikkert3, Valery E P P Lemmens4, Harm J T Rutten5, Johannes H W de Wilt6, Felice N van Erning7. 1. Department of Surgery, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands. Electronic address: nelleke.brouwer@radboudumc.nl. 2. Department of Geriatrics, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands. Electronic address: thea.heil@radboudumc.nl. 3. Department of Geriatrics, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands. Electronic address: marcel.olderikkert@radboudumc.nl. 4. Department of Research, Netherlands Comprehensive Cancer Organization (IKNL), Godebaldkwartier 419, 3511 DT, Utrecht, the Netherlands; Department of Public Health, Erasmus University Medical Center, Doctor Molewaterplein 30, 3015 GD, Rotterdam, the Netherlands. Electronic address: v.lemmens@iknl.nl. 5. Department of Surgery, Catharina Hospital, Michelangelolaan 2, 5623 EJ, Eindhoven, the Netherlands; Department of Surgery, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, the Netherlands. Electronic address: harm.rutten@catharinaziekenhuis.nl. 6. Department of Surgery, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands. Electronic address: hans.dewilt@radboudumc.nl. 7. Department of Research, Netherlands Comprehensive Cancer Organization (IKNL), Godebaldkwartier 419, 3511 DT, Utrecht, the Netherlands. Electronic address: f.vanerning@iknl.nl.
Abstract
AIM OF THE STUDY: Previous studies have shown that older patients benefited less than younger patients from surgical treatment for colorectal cancer (CRC). However, CRC care has advanced over time, and it is time to assess whether the difference in postoperative mortality between older and younger CRC patients is still present. METHODS: Patients with primary stage I-III CRC diagnosed between 2005 and 2016 were selected from the Netherlands Cancer Registry (N = 111,778). Trends in postoperative mortality and 1-year postoperative relative survival (RS) were analysed, stratified according to age (<75 versus ≥75 years) and tumour location (colon versus rectum). One-year postoperative RS was analysed to correct for background mortality in the older population. RESULTS: Between 2005 and 2016, 30-day postoperative mortality showed a stronger decrease for older patients (from 10.0% to 4.0% for colon cancer [p < 0.001] and from 8.3% to 2.7% for rectal cancer [p < 0.001]) compared with younger patients (from 2.0% to 0.9% for colon cancer [p < 0.001] and from 1.4% to 0.7% for rectal cancer [p = 0.01]). Between 2005 and 2016, also 1-year RS increased more for older patients (from 84.8% to 94.6% for colon cancer and from 86.1% to 97.2% for rectal cancer) compared with younger patients (from 94.0% to 97.8% for colon cancer and from 96.3% to 98.8% for rectal cancer). CONCLUSION: Between 2005 and 2016, differences in postoperative mortality between older and younger CRC patients decreased. One-year postoperative RS was almost equal for older and younger patients in 2015-2016. This information is crucial for shared decision-making on surgical treatment.
AIM OF THE STUDY: Previous studies have shown that older patients benefited less than younger patients from surgical treatment for colorectal cancer (CRC). However, CRC care has advanced over time, and it is time to assess whether the difference in postoperative mortality between older and younger CRC patients is still present. METHODS:Patients with primary stage I-III CRC diagnosed between 2005 and 2016 were selected from the Netherlands Cancer Registry (N = 111,778). Trends in postoperative mortality and 1-year postoperative relative survival (RS) were analysed, stratified according to age (<75 versus ≥75 years) and tumour location (colon versus rectum). One-year postoperative RS was analysed to correct for background mortality in the older population. RESULTS: Between 2005 and 2016, 30-day postoperative mortality showed a stronger decrease for older patients (from 10.0% to 4.0% for colon cancer [p < 0.001] and from 8.3% to 2.7% for rectal cancer [p < 0.001]) compared with younger patients (from 2.0% to 0.9% for colon cancer [p < 0.001] and from 1.4% to 0.7% for rectal cancer [p = 0.01]). Between 2005 and 2016, also 1-year RS increased more for older patients (from 84.8% to 94.6% for colon cancer and from 86.1% to 97.2% for rectal cancer) compared with younger patients (from 94.0% to 97.8% for colon cancer and from 96.3% to 98.8% for rectal cancer). CONCLUSION: Between 2005 and 2016, differences in postoperative mortality between older and younger CRC patients decreased. One-year postoperative RS was almost equal for older and younger patients in 2015-2016. This information is crucial for shared decision-making on surgical treatment.
Authors: Lindsey C F De Nes; Thea C Heil; Rob H A Verhoeven; Valery E P P Lemmens; Harm J Rutten; Johannes H W De Wilt; Pauline A J Vissers Journal: Cancers (Basel) Date: 2022-05-31 Impact factor: 6.575
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Authors: Thea C Heil; René J F Melis; Huub A A M Maas; Barbara C van Munster; Marcel G M Olde Rikkert; Johannes H W de Wilt; Eddy M M Adang Journal: PLoS One Date: 2021-12-17 Impact factor: 3.240
Authors: Susanna Niemeläinen; Heini Huhtala; Esa Jämsen; Jyrki Kössi; Jan Andersen; Anu Ehrlich; Eija Haukijärvi; Suvi Koikkalainen; Selja Koskensalo; Anne Mattila; Tarja Pinta; Mirjami Uotila-Nieminen; Hanna Vihervaara; Marja Hyöty Journal: BJS Open Date: 2022-07-07
Authors: Thea C Heil; Emiel G G Verdaasdonk; Huub A A M Maas; Barbara C van Munster; Marcel G M Olde Rikkert; Johannes H W de Wilt; René J F Melis Journal: Ann Surg Oncol Date: 2022-10-05 Impact factor: 4.339
Authors: Seyed M Qaderi; Boris Galjart; Cornelis Verhoef; Gerrit D Slooter; Miriam Koopman; Robert H A Verhoeven; Johannes H W de Wilt; Felice N van Erning Journal: Int J Colorectal Dis Date: 2021-04-04 Impact factor: 2.571