Steven H Jones1, Lisa Riste2, Heather Robinson3, Fiona Holland4, Sarah Peters5, Rosalyn Hartwell6, Katherine Berry5, Mike Fitzsimmons7, Ian Wilson6, Claire Hilton3, Rita Long3, Lucy Bateman5, Emma Weymouth5, Rebecca Owen5, Chris Roberts4, Christine Barrowclough5. 1. Faculty of Health and Medicine, Spectrum Centre for Mental Health Research, Lancaster University, Lancaster, Lancashire UK. Electronic address: s.jones7@lancaster.ac.uk. 2. Faculty of Biology, Medicine and Health, Centre for Primary Care, University of Manchester, Manchester, Greater Manchester, UK. 3. Faculty of Health and Medicine, Spectrum Centre for Mental Health Research, Lancaster University, Lancaster, Lancashire UK. 4. Faculty of Biology, Medicine and Health, Institute of Population Health, University of Manchester, Manchester, Greater Manchester, UK. 5. Faculty of Biology, Medicine and Health, Division of Psychology and Mental Health, University of Manchester, Manchester, Greater Manchester, UK. 6. Greater Manchester Mental Health NHS Foundation Trust, Manchester, Greater Manchester, UK. 7. Lancashire Care NHS Foundation Trust, Preston, Lancashire, UK.
Abstract
BACKGROUND: Alcohol use is a common problem in bipolar disorder (BD) and evidence indicates more promising outcomes for alcohol use than other substances. No trials have evaluated individual integrated motivational interviewing and cognitive behaviour therapy (MI-CBT) for problematic alcohol use in BD. We therefore assessed the feasibility and acceptability of a novel MI-CBT intervention for alcohol use in BD. METHODS: A single blind RCT was conducted to compare MI-CBT plus treatment as usual (TAU) with TAU only. MI-CBT was delivered over 20 sessions with participants followed up at 3, 6, 9 and 12 months post-randomisation. Primary outcomes were the feasibility and acceptability of MI-CBT (recruitment to target, retention to follow-up and therapy, acceptability of therapy and absence of adverse events). We also conducted preliminary analyses of alcohol and mood outcomes (frequency and severity of alcohol use and time to mood relapse). RESULTS: 44 participants were recruited with 75% retention to 6 and 12 months follow-up. Therapy participants attended a mean of 17.6 (SD 4.5) sessions. Therapy alliance and treatment fidelity were acceptable. Qualitative interviews indicated the intervention was experienced as collaborative, and helpful, in addressing mood and alcohol issues, although risk of overconfidence following therapy was also identified. Clinical outcomes did not differ between arms at 12 months follow-up. LIMITATIONS: As a feasibility and acceptability trial any secondary results should be treated with caution. CONCLUSIONS: Integrated MI-CBT is feasible and acceptable, but lack of clinical impact, albeit in a feasibility study, suggests need for further development. Potential adaptations are discussed.
BACKGROUND: Alcohol use is a common problem in bipolar disorder (BD) and evidence indicates more promising outcomes for alcohol use than other substances. No trials have evaluated individual integrated motivational interviewing and cognitive behaviour therapy (MI-CBT) for problematic alcohol use in BD. We therefore assessed the feasibility and acceptability of a novel MI-CBT intervention for alcohol use in BD. METHODS: A single blind RCT was conducted to compare MI-CBT plus treatment as usual (TAU) with TAU only. MI-CBT was delivered over 20 sessions with participants followed up at 3, 6, 9 and 12 months post-randomisation. Primary outcomes were the feasibility and acceptability of MI-CBT (recruitment to target, retention to follow-up and therapy, acceptability of therapy and absence of adverse events). We also conducted preliminary analyses of alcohol and mood outcomes (frequency and severity of alcohol use and time to mood relapse). RESULTS: 44 participants were recruited with 75% retention to 6 and 12 months follow-up. Therapy participants attended a mean of 17.6 (SD 4.5) sessions. Therapy alliance and treatment fidelity were acceptable. Qualitative interviews indicated the intervention was experienced as collaborative, and helpful, in addressing mood and alcohol issues, although risk of overconfidence following therapy was also identified. Clinical outcomes did not differ between arms at 12 months follow-up. LIMITATIONS: As a feasibility and acceptability trial any secondary results should be treated with caution. CONCLUSIONS: Integrated MI-CBT is feasible and acceptable, but lack of clinical impact, albeit in a feasibility study, suggests need for further development. Potential adaptations are discussed.
Authors: Paul Gilbert; Jaskaran K Basran; Joanne Raven; Hannah Gilbert; Nicola Petrocchi; Simone Cheli; Andrew Rayner; Alison Hayes; Kate Lucre; Paschalina Minou; David Giles; Frances Byrne; Elizabeth Newton; Kirsten McEwan Journal: Front Psychol Date: 2022-07-20
Authors: Romain Icick; Ingrid Melle; Bruno Etain; Margrethe Collier Høegh; Sébastien Gard; Sofie R Aminoff; Marion Leboyer; Ole A Andreassen; Raoul Belzeaux; Chantal Henry; Thomas D Bjella; Jean-Pierre Kahn; Nils Eiel Steen; Frank Bellivier; Trine Vik Lagerberg Journal: Front Psychiatry Date: 2022-05-03 Impact factor: 5.435