Shunming Zhang1, Jingzhu Fu1, Qing Zhang2, Li Liu2, Ge Meng1, Zhanxin Yao1,3, Hongmei Wu1, Xue Bao1, Yeqing Gu1, Min Lu4, Shaomei Sun2, Xing Wang2, Ming Zhou2, Qiyu Jia2, Kun Song2, Huiling Xiang4,5, Yuntang Wu1, Kaijun Niu1,2. 1. Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China. 2. Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China. 3. Tianjin Institute of Environmental & Operational Medicine, Tianjin, China. 4. The Third Central Clinical College of Tianjin Medical University, Tianjin, China. 5. Department of Gastroenterology, Tianjin Third Central Hospital, Tianjin, China.
Abstract
BACKGROUND & AIMS: Increased nut consumption has been associated with reduced inflammation, insulin resistance, and oxidative stress. Although these factors are closely involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), few studies have focused on the association between nut consumption and NAFLD in the general population. We aimed to investigate the association of nut consumption and NAFLD in an adult population. METHODS: A total of 23 915 participants from Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study were included in this study. Information on dietary intake was collected using a validated food frequency questionnaire. Abdominal ultrasonography was done to diagnose NAFLD. Multivariable logistic regression was used to assess the association of nut consumption with NAFLD. RESULTS: After adjusting for sociodemographic, medical, dietary, and lifestyle variables, the odds ratios (95% confidence interval) for NAFLD across categories of nut consumption were 1.00 (reference) for <1 time/week, 0.91 (0.82, 1.02) for 1 time/week, 0.88 (0.76, 1.02) for 2-3 times/week, and 0.80 (0.69, 0.92) for ≥4 times/week (P for trend < 0.01). These associations were attenuated but remained significant after further adjustment for blood lipids, glucose, and inflammation markers. CONCLUSIONS: Higher nut consumption was significantly associated with lower prevalence of NAFLD. Further prospective studies and randomized trials are required to ascertain the causal association between nut consumption and NAFLD.
BACKGROUND & AIMS: Increased nut consumption has been associated with reduced inflammation, insulin resistance, and oxidative stress. Although these factors are closely involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), few studies have focused on the association between nut consumption and NAFLD in the general population. We aimed to investigate the association of nut consumption and NAFLD in an adult population. METHODS: A total of 23 915 participants from Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study were included in this study. Information on dietary intake was collected using a validated food frequency questionnaire. Abdominal ultrasonography was done to diagnose NAFLD. Multivariable logistic regression was used to assess the association of nut consumption with NAFLD. RESULTS: After adjusting for sociodemographic, medical, dietary, and lifestyle variables, the odds ratios (95% confidence interval) for NAFLD across categories of nut consumption were 1.00 (reference) for <1 time/week, 0.91 (0.82, 1.02) for 1 time/week, 0.88 (0.76, 1.02) for 2-3 times/week, and 0.80 (0.69, 0.92) for ≥4 times/week (P for trend < 0.01). These associations were attenuated but remained significant after further adjustment for blood lipids, glucose, and inflammation markers. CONCLUSIONS: Higher nut consumption was significantly associated with lower prevalence of NAFLD. Further prospective studies and randomized trials are required to ascertain the causal association between nut consumption and NAFLD.
Authors: Sze-Yen Tan; Ekavi N Georgousopoulou; Barbara R Cardoso; Robin M Daly; Elena S George Journal: BMC Geriatr Date: 2021-05-17 Impact factor: 3.921
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