Literature DB >> 31162691

Minimalist approach meets green chemistry: Synthesis of 18 F- labeled (hetero)aromatics in pure ethanol.

Boris D Zlatopolskiy1,2,3, Johannes Zischler1,2, Philipp Krapf1,2, Raphael Richarz1,2, Katharina Lauchner1,2, Bernd Neumaier1,2,3.   

Abstract

The application of toxic solvents and additives is inevitable for most of the described protocols for 18 F-labeling. Herein, a novel "green" procedure for nucleophilic aromatic radiofluorination of highly activated (hetero)aromatic substrates in pure EtOH is described. Using this method a series of 18 F-labeled (hetero)arenes have been synthesized in radiochemical yields (RCYs) of up to 97%.
© 2019 John Wiley & Sons, Ltd.

Entities:  

Keywords:  (hetero)aromatics; PSMA; green chemistry; minimalist approach; radiofluorination; sustainability

Mesh：

Substances：

Year:  2019        PMID： 31162691     DOI： 10.1002/jlcr.3776

Source DB:  PubMed          Journal:  J Labelled Comp Radiopharm        ISSN： 0362-4803            Impact factor:   1.921


  3 in total

Review 1.  Strained Ammonium Precursors for Radiofluorinations.

Authors:  Falco Reissig; Constantin Mamat
Journal:  ChemistryOpen       Date:  2022-06       Impact factor: 2.630

2.  Alcohol-Supported Cu-Mediated 18F-Fluorination of Iodonium Salts under "Minimalist" Conditions.

Authors:  Victoriya V Orlovskaya; Daniel J Modemann; Olga F Kuznetsova; Olga S Fedorova; Elizaveta A Urusova; Niklas Kolks; Bernd Neumaier; Raisa N Krasikova; Boris D Zlatopolskiy
Journal:  Molecules       Date:  2019-09-03       Impact factor: 4.411

3.  Late-Stage Copper-Catalyzed Radiofluorination of an Arylboronic Ester Derivative of Atorvastatin.

Authors:  Gonçalo S Clemente; Tryfon Zarganes-Tzitzikas; Alexander Dömling; Philip H Elsinga
Journal:  Molecules       Date:  2019-11-20       Impact factor: 4.411
  3 in total

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