Literature DB >> 3116265

A novel family of variable region genes of the human immunoglobulin heavy chain.

K H Lee1, F Matsuda, T Kinashi, M Kodaira, T Honjo.   

Abstract

We isolated and sequenced six variable-region (V) gene segments of the human immunoglobulin heavy-chain (H) using the V71-2 segment as probe. These VH segments were more than 90% homologous to each other and less than 65% homologous to members of the three known VH families. The VH fragments hybridized to an identical set of restriction fragments on Southern blots of human placenta DNA. The new family was designated as the VH-IV family. The complexity of the VH-IV family was estimated to be at least nine genes, of which the sequenced seven were functional genes. The VH-IV family is homologous (76%) to the mouse Vh36-60 family.

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Year:  1987        PMID： 3116265     DOI： 10.1016/0022-2836(87)90482-7

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  60 in total

1.  Direct detection of insertion/deletion polymorphisms in an autosomal region by analyzing high-density markers in individual spermatozoa.

Authors:  Sreemanta Pramanik; Honghua Li
Journal:  Am J Hum Genet       Date:  2002-11-19       Impact factor: 11.025

2.  Sequence analyses of three immunoglobulin G anti-virus antibodies reveal their utilization of autoantibody-related immunoglobulin Vh genes, but not V lambda genes.

Authors:  D F Huang; T Olee; Y Masuho; Y Matsumoto; D A Carson; P P Chen
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

3.  Characterization of the cDNA of a broadly reactive neutralizing human anti-gp120 monoclonal antibody.

Authors:  W A Marasco; J Bagley; C Zani; M Posner; L Cavacini; W A Haseltine; J Sodroski
Journal:  J Clin Invest       Date:  1992-10       Impact factor: 14.808

4.  Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift.

Authors:  J M Bye; C Carter; Y Cui; B D Gorick; S Songsivilai; G Winter; N C Hughes-Jones; J D Marks
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

5.  Immunoglobulin variable heavy chain cDNA sequence from a patient with X-linked agammaglobulinemia.

Authors:  F Mortari; H D Ochs; R J Wedgwood; H W Schroeder
Journal:  Nucleic Acids Res       Date:  1991-02-11       Impact factor: 16.971

6.  Nucleotide sequences and three-dimensional modelling of the VH and VL domains of two human monoclonal antibodies specific for the D antigen of the human Rh-blood-group system.

Authors:  N C Hughes-Jones; J M Bye; D Beale; J Coadwell
Journal:  Biochem J       Date:  1990-05-15       Impact factor: 3.857

7.  Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life.

Authors:  H W Schroeder; J Y Wang
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

8.  Organization of the immunoglobulin heavy chain variable region gene complex in human lupus.

Authors:  M Zouali; P Chastagner; A Abadie; J Thèze
Journal:  Immunogenetics       Date:  1990       Impact factor: 2.846

9.  Somatic diversification in the heavy chain variable region genes expressed by human autoantibodies bearing a lupus-associated nephritogenic anti-DNA idiotype.

Authors:  C Demaison; P Chastagner; J Thèze; M Zouali
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-18       Impact factor: 11.205

10.  Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments.

Authors:  P Riboldi; G Gaidano; E W Schettino; T G Steger; D M Knowles; R Dalla-Favera; P Casali
Journal:  Blood       Date:  1994-05-15       Impact factor: 22.113
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