Literature DB >> 31161954

The Genetic Association of IFN-λs with Human Inflammatory Disorders Remains a Conundrum.

Sreedhar Chinnaswamy1, Marek L Kowalski2,3.   

Abstract

Type III Interferons (IFNs) or lambda IFNs (IFN-λs or IFNLs) although are primarily antiviral cytokines, may have roles to play in shaping immune responses, including those during inflammation. Genetic variants within the IFNL locus have been shown to be associated with various inflammatory conditions in humans ranging from metabolic to autoimmune and allergic diseases. The mechanism behind these genetic associations is not clear. Appropriate data analysis methods and functional evidence should be complimentarily used to identify the causal variants and mechanisms.

Entities:  

Keywords:  IFN-λ3; IFN-λ4; IFNL locus; SNPs; inflammatory disorders

Mesh：

Substances：

Year:  2019        PMID： 31161954      PMCID： PMC7176482          DOI： 10.1089/jir.2019.0009

Source DB:  PubMed          Journal:  J Interferon Cytokine Res        ISSN： 1079-9907            Impact factor:   2.607


  23 in total

Review 1.  Identifying causal variants at the interferon lambda locus in case-control studies: Utilizing non-synonymous variant rs117648444 to probe the role of IFN-λ4.

Authors:  Anand Bhushan; Sreedhar Chinnaswamy
Journal:  Gene       Date:  2018-04-27       Impact factor: 3.688

2.  IL28B rs12979860 genotype and spontaneous clearance of hepatitis C virus in a multi-ethnic cohort of injection drug users: evidence for a supra-additive association.

Authors:  Fatma M Shebl; Ruth M Pfeiffer; Dianna Buckett; Brian Muchmore; Sabrina Chen; Myhanh Dotrang; Ludmila Prokunina-Olsson; Brian R Edlin; Thomas R O'Brien
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Review 3.  Interferon Lambda: Toward a Dual Role in Cancer.

Authors:  Ahmed Lasfar; Andrew Zloza; Ann W Silk; Leonard Y Lee; Karine A Cohen-Solal
Journal:  J Interferon Cytokine Res       Date:  2018-07-18       Impact factor: 2.607

4.  Genetic variations in IL28B and allergic disease in children.

Authors:  Silvana Gaudieri; Michaela Lucas; Andrew Lucas; Elizabeth McKinnon; Hiba Albloushi; Andri Rauch; Julia di Iulio; David Martino; Susan L Prescott; Meri K Tulic
Journal:  PLoS One       Date:  2012-01-25       Impact factor: 3.240

5.  The association between interleukin-28B gene polymorphisms as a potential biomarker and the risk of chronic Periodontitis in an Iranian population.

Authors:  Zahra Heidari; Bita Moudi; Hamidreza Mahmoudzadeh-Sagheb; Mehrnoosh Moudi
Journal:  Head Face Med       Date:  2017-06-27       Impact factor: 2.151

6.  IFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes.

Authors:  Adrian Egli; Jyotshna Mandal; Desiree M Schumann; Michael Roth; Brad Thomas; D Lorne Tyrrell; Francesco Blasi; Kostantinos Kostikas; Wim Boersma; Branislava Milenkovic; Alicia Lacoma; Katharina Rentsch; Gernot G U Rohde; Renaud Louis; Joachim G Aerts; Tobias Welte; Antoni Torres; Michael Tamm; Daiana Stolz
Journal:  BMC Pulm Med       Date:  2018-03-21       Impact factor: 3.317

7.  Correction: Report of the inaugural Interferon Research Summit: interferon in inflammatory diseases.

Authors: 
Journal:  Lupus Sci Med       Date:  2018-09-04

8.  Interferon-λ3/4 genetic variants and interferon-λ3 serum levels are biomarkers of lupus nephritis and disease activity in Taiwanese.

Authors:  Ji-Yih Chen; Chin-Man Wang; Tai-Di Chen; Yeong-Jian Jan Wu; Jing-Chi Lin; Ling Ying Lu; Jianming Wu
Journal:  Arthritis Res Ther       Date:  2018-08-29       Impact factor: 5.156

Review 9.  Lambda interferons come to light: dual function cytokines mediating antiviral immunity and damage control.

Authors:  Evangelos Andreakos; Ivan Zanoni; Ioanna E Galani
Journal:  Curr Opin Immunol       Date:  2018-11-03       Impact factor: 7.486

Review 10.  Guarding the frontiers: the biology of type III interferons.

Authors:  Andreas Wack; Ewa Terczyńska-Dyla; Rune Hartmann
Journal:  Nat Immunol       Date:  2015-08       Impact factor: 25.606
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  2 in total

1.  Distinct molecular phenotypes involving several human diseases are induced by IFN-λ3 and IFN-λ4 in monocyte-derived macrophages.

Authors:  Manjarika De; Anand Bhushan; William S Grubbe; Subhajit Roy; Juan L Mendoza; Sreedhar Chinnaswamy
Journal:  Genes Immun       Date:  2022-02-03       Impact factor: 4.248

2.  Monocytes differentiated into macrophages and dendritic cells in the presence of human IFN-λ3 or IFN-λ4 show distinct phenotypes.

Authors:  Manjarika De; Anand Bhushan; Sreedhar Chinnaswamy
Journal:  J Leukoc Biol       Date:  2020-11-17       Impact factor: 6.011
  2 in total

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