Norberto K Kavabata1, Décio N Caly2, Ting H Ching3, Antonio J Gonçalves4, Luis P Kowalski5, Cláudio R Cernea6. 1. Department of Surgery, Head and Neck Surgery Division, Statistic Division of Santa Casa de Sao Paulo School of Medical Sciences, Rua Doutor Cesário Mota Junior, 112-Bairro: Vila Buarque, São Paulo/SP, CEP: 01221-020, Brazil. cabpesc@santacasasp.org.br. 2. Department of Pathology of Hospital Heliópolis, Rua: Cônego Xavier, 276, São Paulo/SP, CEP 04231-030, Brazil. 3. Department of Social Medicine, Statistic Division of Santa Casa de Sao Paulo School of Medical Sciences, Rua Doutor Cesário Mota Junior, 112, São Paulo/SP, CEP: 01221-020, Brazil. 4. Department of Surgery, Head and Neck Surgery Division, Statistic Division of Santa Casa de Sao Paulo School of Medical Sciences, Rua Doutor Cesário Mota Junior, 112-Bairro: Vila Buarque, São Paulo/SP, CEP: 01221-020, Brazil. 5. Department of Head and Neck Surgery and Otorhinolaryngology of Hospital A.C.Camargo, Rua Prof. Antonio Prudente, 211, São Paulo/SP, CEP 01509-010, Brazil. 6. Department of Head and Neck Surgery of Hospital das Clínicas, University of São Paulo School of Medicine, Av. Dr. Enéas de Carvalho Aguiar, 255, São Paulo/SP, CEP 05403-000, Brazil.
Abstract
PURPOSE: Many authors have described clinicopathologic parameters as factors related to cervical lymph node metastasis development in CN0 stage lip cancer. However, predictive factors for occult lymph node metastasis and criteria for elective neck dissection, especially for early tumour, remain undefined. METHODS: A multi-institutional study with 193 consecutive patients with early lip SCC treated from January 1990 to March 2006 was carried out retrospectively to determine factors predicting occult metastasis. RESULTS: The overall late LNM rate was 13% (25/193). In the multivariate logistic regression study, tumour size and pattern of tumour invasion were factors related to the occurrence of late LNM with rates of sensitivity, specifity and accuracy for occult LNM prediction of 50%, 89.5% and 87%, respectively. CONCLUSION: Our results indicate that patients with stage I and II SCC of the lip with tumour size greater than 18 mm and more aggressive pattern of invasion must be considered a high-risk group for LNM and an END should be performed.
PURPOSE: Many authors have described clinicopathologic parameters as factors related to cervical lymph node metastasis development in CN0 stage lip cancer. However, predictive factors for occult lymph node metastasis and criteria for elective neck dissection, especially for early tumour, remain undefined. METHODS: A multi-institutional study with 193 consecutive patients with early lip SCC treated from January 1990 to March 2006 was carried out retrospectively to determine factors predicting occult metastasis. RESULTS: The overall late LNM rate was 13% (25/193). In the multivariate logistic regression study, tumour size and pattern of tumour invasion were factors related to the occurrence of late LNM with rates of sensitivity, specifity and accuracy for occult LNM prediction of 50%, 89.5% and 87%, respectively. CONCLUSION: Our results indicate that patients with stage I and II SCC of the lip with tumour size greater than 18 mm and more aggressive pattern of invasion must be considered a high-risk group for LNM and an END should be performed.
Authors: Radouane El Ayachy; Roger Sun; Kanta Ka; Adrien Laville; Anne-Sophie Duhamel; Anne Tailleur; Isabelle Dumas; Sophie Bockel; Sophie Espenel; Pierre Blanchard; Yungan Tao; Stéphane Temam; Antoine Moya-Plana; Christine Haie-Meder; Cyrus Chargari Journal: Cancers (Basel) Date: 2021-03-19 Impact factor: 6.639