| Literature DB >> 31160823 |
Mónica García-Gallo1, Maria Teresa Martin1, Daniel Perez-Zsolt2,3, Itziar Erkizia2, Maria Pino2, Susana Benet2,3, Jakub Chojnacki2, María Teresa Fernández-Figueras4,5,6, Dolores Guerrero7, Victor Urrea2, Xabier Muñiz-Trabudua2,3, Leonor Kremer1, Javier Martinez-Picado8,9,10, Nuria Izquierdo-Useros11,12.
Abstract
Several Ebola viruses cause outbreaks of lethal haemorrhagic fever in humans, but developing therapies tackle only Zaire Ebola virus. Dendritic cells (DCs) are targets of this infection in vivo. Here, we found that Ebola virus entry into activated DCs requires the sialic acid-binding Ig-like lectin 1 (Siglec-1/CD169), which recognizes sialylated gangliosides anchored to viral membranes. Blockage of the Siglec-1 receptor by anti-Siglec-1 monoclonal antibodies halted Ebola viral uptake and cytoplasmic entry, offering cross-protection against other ganglioside-containing viruses such as human immunodeficiency virus type 1.Entities:
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Year: 2019 PMID： 31160823 DOI： 10.1038/s41564-019-0453-2
Source DB: PubMed Journal: Nat Microbiol ISSN： 2058-5276 Impact factor: 17.745