Wake Up and Smell the Fusions: Single-Modality Molecular Testing Misses Drivers.

Multitarget assays have become common in clinical molecular diagnostic laboratories. However, all assays, no matter how well designed, have inherent gaps due to technical and biological limitations. In some clinical cases, testing by multiple methodologies is needed to address these gaps and ensure the most accurate molecular diagnoses.See related article by Benayed et al., p. 4712. ©2019 American Association for Cancer Research.