Anita van Zwieten1, Germaine Wong2, Marinella Ruospo3, Suetonia C Palmer4, Armando Teixeira-Pinto5, Maria Rosaria Barulli6, Annalisa Iurillo6, Valeria Saglimbene7, Patrizia Natale8, Letizia Gargano3, Marco Murgo3, Clement T Loy9, Rosanna Tortelli6, Jonathan C Craig10, David W Johnson11, Marcello Tonelli12, Jörgen Hegbrant3, Charlotta Wollheim3, Giancarlo Logroscino13, Giovanni F M Strippoli14. 1. Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, Sydney, Australia; Centre for Kidney Research, Children's Hospital at Westmead, Westmead, Australia. Electronic address: anitavanzwieten90@gmail.com. 2. Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, Sydney, Australia; Centre for Kidney Research, Children's Hospital at Westmead, Westmead, Australia; Department of Renal Medicine, Westmead Hospital, Westmead, Australia. 3. Diaverum Medical-Scientific Office, Lund, Sweden. 4. Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand. 5. Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, Sydney, Australia; Centre for Kidney Research, Children's Hospital at Westmead, Westmead, Australia. 6. Neurodegenerative Diseases Unit, Department of Clinical Research in Neurology, University of Bari "A. Moro," "Pia Fondazione Cardinale G. Panico," Tricase, Lecce, Italy. 7. Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, Sydney, Australia; Diaverum Medical-Scientific Office, Lund, Sweden. 8. Diaverum Medical-Scientific Office, Lund, Sweden; Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare, Bari, Italy. 9. Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, Sydney, Australia; The Garvan Institute of Medical Research, Sydney, Australia. 10. College of Medicine and Public Health, Flinders University, Adelaide, Australia. 11. Department of Nephrology, Princess Alexandra Hospital, Woolloongabba, Australia; Translational Research Institute, University of Queensland, Woolloongabba, Australia. 12. Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. 13. Neurodegenerative Diseases Unit, Department of Clinical Research in Neurology, University of Bari "A. Moro," "Pia Fondazione Cardinale G. Panico," Tricase, Lecce, Italy; Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "A. Moro", Bari, Italy. 14. Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, Sydney, Australia; Diaverum Medical-Scientific Office, Lund, Sweden; Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare, Bari, Italy; Diaverum Academy, Diaverum, Bari, Italy.
Abstract
RATIONALE & OBJECTIVE: In the general population, cognitive impairment is associated with increased mortality, and higher levels of education are associated with lower risks for cognitive impairment and mortality. These associations are not well studied in patients receiving long-term hemodialysis and were the focus of the current investigation. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: Adult hemodialysis patients treated in 20 Italian dialysis clinics. EXPOSURES: Patients' cognitive function across 5 domains (memory, attention, executive function, language, and perceptual-motor function), measured using a neuropsychological assessment comprising 10 tests; and patients' self-reported years of education. OUTCOME: All-cause mortality. ANALYTICAL APPROACH: Nested multivariable Cox regression models were used to examine associations of cognition (any domain impaired, number of domains impaired, and global function score from principal components analysis of unadjusted test scores) and education with mortality and whether there were interactions between them. RESULTS: 676 (70.6%) patients participated, with a median age of 70.9 years and including 38.8% women. Cognitive impairment was present in 79.4% (527/664; 95% CI, 76.3%-82.5%). During a median follow-up of 3.3 years (1,874 person-years), 206 deaths occurred. Compared to no cognitive impairment, adjusted HRs for mortality were 1.77 (95% CI, 1.07-2.93) for any impairment, 1.48 (95% CI, 0.82-2.68) for 1 domain impaired, 1.88 (95% CI, 1.01-3.53) for 2 domains, and 2.01 (95% CI, 1.14-3.55) for 3 to 5 domains. The adjusted HR was 0.68 (95% CI, 0.51-0.92) per standard deviation increase in global cognitive function score. Compared with primary or lower education, adjusted HRs were 0.79 (95% CI, 0.53-1.20) for lower secondary and 1.13 (95% CI, 0.80-1.59) for upper secondary or higher. The cognition-by-education interaction was not significant (P=0.7). LIMITATIONS: Potential selection bias from nonparticipation and missing data; no data for cognitive decline; associations with education were not adjusted for other socioeconomic factors. CONCLUSIONS: Cognitive impairment is associated with premature mortality in hemodialysis patients. Education does not appear to be associated with mortality.
RATIONALE & OBJECTIVE: In the general population, cognitive impairment is associated with increased mortality, and higher levels of education are associated with lower risks for cognitive impairment and mortality. These associations are not well studied in patients receiving long-term hemodialysis and were the focus of the current investigation. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: Adult hemodialysis patients treated in 20 Italian dialysis clinics. EXPOSURES: Patients' cognitive function across 5 domains (memory, attention, executive function, language, and perceptual-motor function), measured using a neuropsychological assessment comprising 10 tests; and patients' self-reported years of education. OUTCOME: All-cause mortality. ANALYTICAL APPROACH: Nested multivariable Cox regression models were used to examine associations of cognition (any domain impaired, number of domains impaired, and global function score from principal components analysis of unadjusted test scores) and education with mortality and whether there were interactions between them. RESULTS: 676 (70.6%) patients participated, with a median age of 70.9 years and including 38.8% women. Cognitive impairment was present in 79.4% (527/664; 95% CI, 76.3%-82.5%). During a median follow-up of 3.3 years (1,874 person-years), 206 deaths occurred. Compared to no cognitive impairment, adjusted HRs for mortality were 1.77 (95% CI, 1.07-2.93) for any impairment, 1.48 (95% CI, 0.82-2.68) for 1 domain impaired, 1.88 (95% CI, 1.01-3.53) for 2 domains, and 2.01 (95% CI, 1.14-3.55) for 3 to 5 domains. The adjusted HR was 0.68 (95% CI, 0.51-0.92) per standard deviation increase in global cognitive function score. Compared with primary or lower education, adjusted HRs were 0.79 (95% CI, 0.53-1.20) for lower secondary and 1.13 (95% CI, 0.80-1.59) for upper secondary or higher. The cognition-by-education interaction was not significant (P=0.7). LIMITATIONS: Potential selection bias from nonparticipation and missing data; no data for cognitive decline; associations with education were not adjusted for other socioeconomic factors. CONCLUSIONS:Cognitive impairment is associated with premature mortality in hemodialysis patients. Education does not appear to be associated with mortality.
Authors: Janine F Farragher; Katherine E Stewart; Tyrone G Harrison; Lisa Engel; Samantha E Seaton; Brenda R Hemmelgarn Journal: Syst Rev Date: 2020-03-17