Moises Rodriguez-Gonzalez1,2, Isabel Benavente-Fernandez2,3, Ana Castellano-Martinez2,4, Alfonso Maria Lechuga-Sancho2,5, Simon Pedro Lubian-Lopez2,3. 1. Pediatric Cardiology Department, Puerta del Mar University Hospital, Cádiz, Spain. 2. Biomedical Research and Innovation Institute of Cádiz (INiBICA), Research Unit of Puerta del Mar University Hospital, University of Cádiz, Spain. 3. Neonatology Department, Puerta del Mar University Hospital, Cádiz, Spain. 4. Pediatric Nephrology Department, Puerta del Mar University Hospital, Cádiz, Spain. 5. Maternal and Child Health and Radiology Department, School of Medicine, University of Cádiz, Spain.
Abstract
Aim: To explore NT-proBNP as biomarker for pulmonary hypertension (PH) in infants with respiratory syncytial virus infection (RSVI). Patients & methods: We prospectively enrolled 93 healthy infants with RSVI aged 1-12 months. NT-proBNP determination and echocardiography were performed at admission. Results: PH was found in 22% of patients and associated with a severe course of the disease. NT-proBNP >1635 pg/ml resulted an independent predictor for PH (odds ratio: 16.46 [95% CI: 4.10-66; p < 0.001]). The diagnostic performance of NT-proBNP to detect PH in RSVI was high (area under receiver operator curve of 0.932 [95% CI: 0.883-0.981; p < 0.001]). Conclusions: The presence of PH in healthy infants with RSVI is associated with worse outcomes. NT-proBNP resulted an accurate biomarker for PH in this setting.
Aim: To explore NT-proBNP as biomarker for pulmonary hypertension (PH) in infants with respiratory syncytial virus infection (RSVI). Patients & methods: We prospectively enrolled 93 healthy infants with RSVI aged 1-12 months. NT-proBNP determination and echocardiography were performed at admission. Results:PH was found in 22% of patients and associated with a severe course of the disease. NT-proBNP >1635 pg/ml resulted an independent predictor for PH (odds ratio: 16.46 [95% CI: 4.10-66; p < 0.001]). The diagnostic performance of NT-proBNP to detect PH in RSVI was high (area under receiver operator curve of 0.932 [95% CI: 0.883-0.981; p < 0.001]). Conclusions: The presence of PH in healthy infants with RSVI is associated with worse outcomes. NT-proBNP resulted an accurate biomarker for PH in this setting.
Authors: Moises Rodriguez-Gonzalez; Ana Castellano-Martinez; Helena Maria Cascales-Poyatos; Alvaro Antonio Perez-Reviriego Journal: World J Clin Cases Date: 2020-11-06 Impact factor: 1.337
Authors: Moises Rodriguez-Gonzalez; Patricia Rodriguez-Campoy; Ana Estalella-Mendoza; Ana Castellano-Martinez; Jose Carlos Flores-Gonzalez Journal: Tomography Date: 2022-01-05
Authors: Luan D Vu; Jordy Saravia; Sridhar Jaligama; Rajshri V Baboeram Panday; Ryan D Sullivan; Salvatore Mancarella; Stephania A Cormier; Dai Kimura Journal: Am J Physiol Heart Circ Physiol Date: 2021-06-25 Impact factor: 5.125