James S Graydon1, Karla Claudio2, Seth Baker3, Mohan Kocherla1, Mark Ferreira1, Abiel Roche-Lima4, Jovaniel Rodríguez-Maldonado4, Jorge Duconge2, Gualberto Ruaño1. 1. Laboratory of Personalized Health, Genomas, Inc., Hartford, CT 06102, USA. 2. Pharmaceutical Sciences department, University of Puerto Rico School of Pharmacy, San Juan, PR 00936, USA. 3. Clinical Laboratory Partners, Hartford Healthcare, Hartford, CT 06102, USA. 4. Center for Collaborative Research in Health Disparities, University of Puerto Rico School of Medicine, San Juan, PR 00936, USA.
Abstract
Aim: Variants of the MTHFR gene have been associated with a wide range of diseases. Materials & methods: The present study analyzed data from clinical genotyping of MTHFR 677C>T and 1298A>C in 1405 patients in urban primary care settings. Results: Striking differences in ethnogeographic frequencies of MTHFR polymorphisms were observed. African-Americans appear to be protected from MTHFR deficiency. Hispanics and Caucasians may be at elevated risk due to increased frequencies of 677C>T and 1298A>C, respectively. Conclusion: Individuals carrying mutations for both genes were rare and doubly homozygous mutants were absent, suggesting the TTcc is extremely rare in the greater population. The results suggest multilocus MTHFR genotyping may yield deeper insight into the ethnogeographic association between MTHFR variants and disease.
Aim: Variants of the MTHFR gene have been associated with a wide range of diseases. Materials & methods: The present study analyzed data from clinical genotyping of MTHFR 677C>T and 1298A>C in 1405 patients in urban primary care settings. Results: Striking differences in ethnogeographic frequencies of MTHFR polymorphisms were observed. African-Americans appear to be protected from MTHFR deficiency. Hispanics and Caucasians may be at elevated risk due to increased frequencies of 677C>T and 1298A>C, respectively. Conclusion: Individuals carrying mutations for both genes were rare and doubly homozygous mutants were absent, suggesting the TTcc is extremely rare in the greater population. The results suggest multilocus MTHFR genotyping may yield deeper insight into the ethnogeographic association between MTHFR variants and disease.
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