Sagar Ramdas1, Farzana Yousaf1, Madhur D Shastri1, Troy Wanandy1,2, Syed T R Zaidi1,2, Manish Khandagale3, Matthew Jose4,5, Rahul P Patel1. 1. Division of Pharmacy, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia. 2. Pharmacy Department, Royal Hobart Hospital, Hobart, Tasmania, Australia. 3. Division of Chemistry, Faculty of Science, Engineering and Technology, Australian Centre for Research on Separation Science, University of Tasmania, Hobart, Tasmania, Australia. 4. Division of Medicine, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia. 5. Nephrology Department, Royal Hobart Hospital, Hobart, Tasmania, Australia.
Abstract
BACKGROUND: Intraperitoneal daptomycin is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by vancomycin-resistant bacteria. This study investigated the stability of daptomycin in a pH-neutral PD solution. METHODS: Reconstituted solution of daptomycin was added to a total of nine PD bags to obtain a concentration of 20 mg/L and stored at 1 of 3 different temperatures: 4 or 25°C for up to 168 h or 37°C for up to 48 h. Stabilities were determined by visual inspection, pH measurement and high-performance liquid chromatography. RESULTS: Daptomycin retained more than 90% of its initial concentration for 120, 72 and 12 h at 4°C, 25°C and 37°C, respectively. No physical precipitation or pH change was observed during the study. CONCLUSIONS: Daptomycin in a pH-neutral PD solution is physically and chemically stable for 120 and 12 h at 4°C and 37°C, respectively.
BACKGROUND: Intraperitoneal daptomycin is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by vancomycin-resistant bacteria. This study investigated the stability of daptomycin in a pH-neutral PD solution. METHODS: Reconstituted solution of daptomycin was added to a total of nine PD bags to obtain a concentration of 20 mg/L and stored at 1 of 3 different temperatures: 4 or 25°C for up to 168 h or 37°C for up to 48 h. Stabilities were determined by visual inspection, pH measurement and high-performance liquid chromatography. RESULTS: Daptomycin retained more than 90% of its initial concentration for 120, 72 and 12 h at 4°C, 25°C and 37°C, respectively. No physical precipitation or pH change was observed during the study. CONCLUSIONS: Daptomycin in a pH-neutral PD solution is physically and chemically stable for 120 and 12 h at 4°C and 37°C, respectively.
Authors: Philip Kam-Tao Li; Cheuk Chun Szeto; Beth Piraino; Judith Bernardini; Ana E Figueiredo; Amit Gupta; David W Johnson; Ed J Kuijper; Wai-Choong Lye; William Salzer; Franz Schaefer; Dirk G Struijk Journal: Perit Dial Int Date: 2010 Jul-Aug Impact factor: 1.756
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