Literature DB >> 3115592

Mutants of GAL4 protein altered in an activation function.

G Gill1, M Ptashne.   

Abstract

Activating region I of GAL4 has been defined as a region 48 amino acids long which, when attached to GAL4's DNA-binding domain, activates transcription in yeast. Here we describe mutants bearing changes in and around this highly acidic activating region. We find mutations that increase the activation function invariably increase the acidity of the region and some but not all of the mutations that decrease the activation function decrease the acidity of the region.

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Year:  1987        PMID： 3115592     DOI： 10.1016/0092-8674(87)90016-x

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  105 in total

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10.  Genetic analysis indicates that the human foamy virus Bel-1 protein contains a transcription activation domain of the acidic class.

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