Eric Hermand1,2, Aurélien Pichon3, François J Lhuissier4,5, Jean-Paul Richalet4,6. 1. Laboratoire HAVAE 'Handicap, Activité, Vieillissement, Autonomie, Environnement', E6310, Université de Limoges, Faculté Des Sciences Et Techniques, 123 avenue Albert Thomas, 87060, Limoges Cedex, France. eric.hermand17@gmail.com. 2. Sorbonne Paris Cité, Laboratoire "Hypoxie & Poumon", E2363, Université Paris 13, Bobigny, France. eric.hermand17@gmail.com. 3. Laboratoire MOVE, Université de Poitiers, E6314, Poitiers, France. 4. Sorbonne Paris Cité, Laboratoire "Hypoxie & Poumon", E2363, Université Paris 13, Bobigny, France. 5. Assistance Publique-Hôpitaux de Paris, Hôpital Avicenne, Service de Physiologie, Explorations Fonctionnelles Et Médecine du Sport, 93009, Bobigny, France. 6. Département Médical, Institut National de L'Expertise Et de La Performance, 75012, Paris, France.
Abstract
PURPOSE: Heart rate variability (HRV) may be influenced by several factors, such as environment (hypoxia, hyperoxia, hypercapnia) or physiological demand (exercise). In this retrospective study, we tested the hypothesis that inter-beat (RR) intervals in healthy subjects exercising under various environmental stresses exhibit oscillations at the same frequency than ventilatory oscillations. METHODS: Spectra from RR intervals and ventilation ([Formula: see text]E) were collected from 37 healthy young male subjects who participated in 5 previous studies focused on ventilatory oscillations (or periodic breathing) during exercise in hypoxia, hyperoxia and hypercapnia. Bland and Altman test and multivariate regressions were then performed to compare respective frequencies and changes in peak powers of the two signals. RESULTS: Fast Fourier analysis of RR and [Formula: see text]E signals showed that RR was oscillating at the same frequency than periodic breathing, i.e., ~ 0.09 Hz (11 s). During exercise, in these various conditions, the difference between minimum and maximum HRV peak power was positively correlated to the same change in ventilation peak power (P < 0.05). Low-frequency (LF) peak power was correlated to tidal volume (P < 0.01) and breathing frequency (P < 0.001). CONCLUSIONS: This study suggests that low-frequency ventilatory oscillations in hypoxia are a major contributor to the LF band power of heart rate variability. CLINICAL TRIAL REG. NO.: NCT02201875.
PURPOSE: Heart rate variability (HRV) may be influenced by several factors, such as environment (hypoxia, hyperoxia, hypercapnia) or physiological demand (exercise). In this retrospective study, we tested the hypothesis that inter-beat (RR) intervals in healthy subjects exercising under various environmental stresses exhibit oscillations at the same frequency than ventilatory oscillations. METHODS: Spectra from RR intervals and ventilation ([Formula: see text]E) were collected from 37 healthy young male subjects who participated in 5 previous studies focused on ventilatory oscillations (or periodic breathing) during exercise in hypoxia, hyperoxia and hypercapnia. Bland and Altman test and multivariate regressions were then performed to compare respective frequencies and changes in peak powers of the two signals. RESULTS: Fast Fourier analysis of RR and [Formula: see text]E signals showed that RR was oscillating at the same frequency than periodic breathing, i.e., ~ 0.09 Hz (11 s). During exercise, in these various conditions, the difference between minimum and maximum HRV peak power was positively correlated to the same change in ventilation peak power (P < 0.05). Low-frequency (LF) peak power was correlated to tidal volume (P < 0.01) and breathing frequency (P < 0.001). CONCLUSIONS: This study suggests that low-frequency ventilatory oscillations in hypoxia are a major contributor to the LF band power of heart rate variability. CLINICAL TRIAL REG. NO.: NCT02201875.
Entities:
Keywords:
Control of ventilation; Exercise; Heart rate variability; Hypoxia; Periodic breathing
Authors: Richard S T Leung; John S Floras; Geraldo Lorenzi-Filho; Fiona Rankin; Peter Picton; T Douglas Bradley Journal: Am J Respir Crit Care Med Date: 2003-03-05 Impact factor: 21.405
Authors: P Ponikowski; T P Chua; M Piepoli; W Banasiak; S D Anker; R Szelemej; W Molenda; K Wrabec; A Capucci; A J Coats Journal: Am J Cardiol Date: 1998-08-01 Impact factor: 2.778