Sultana Monira Hussain1,2, Chloe Dawson1,2, Yuanyuan Wang1,2, Andrew M Tonkin1,2, Louisa Chou1,2, Anita E Wluka1,2, Flavia M Cicuttini3,4. 1. From the School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne; Australian National University (ANU) College of Health and Medicine, Canberra; The Alfred Hospital, Melbourne, Australia. 2. S.M. Hussain, PhD, Research Fellow, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital; C. Dawson, MPH, Medical Student, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, and ANU College of Health and Medicine; Y. Wang, PhD, Senior Research Fellow, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital; A.M. Tonkin, PhD, Professor, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital; L. Chou, FRACP, Consultant, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, and The Alfred Hospital; A.E. Wluka, PhD, Professor, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital; F.M. Cicuttini, PhD, Professor, School of Public Health and Preventive Medicine, Monash University. S.M. Hussain and C. Dawson are joint first authors. 3. From the School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne; Australian National University (ANU) College of Health and Medicine, Canberra; The Alfred Hospital, Melbourne, Australia. flavia.cicuttini@monash.edu. 4. S.M. Hussain, PhD, Research Fellow, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital; C. Dawson, MPH, Medical Student, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, and ANU College of Health and Medicine; Y. Wang, PhD, Senior Research Fellow, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital; A.M. Tonkin, PhD, Professor, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital; L. Chou, FRACP, Consultant, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, and The Alfred Hospital; A.E. Wluka, PhD, Professor, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital; F.M. Cicuttini, PhD, Professor, School of Public Health and Preventive Medicine, Monash University. S.M. Hussain and C. Dawson are joint first authors. flavia.cicuttini@monash.edu.
Abstract
OBJECTIVE: Vascular pathology (changes in blood vessels) and osteoarthritis (OA) are both common chronic conditions associated with aging and obesity, but whether vascular pathology is a risk factor for OA is unclear. The aim of this study was to systematically review the evidence for an association between vascular pathology and risk of joint-specific OA. METHODS: Scopus, Ovid Medline, and EMBASE were searched from inception to February 2019. MeSH terms and keywords were used to identify studies examining the association between vascular pathology and OA. Two reviewers independently extracted the data and assessed the methodological quality. Qualitative evidence synthesis was performed. RESULTS: Fifteen studies with high (n = 3), fair (n = 3), or low (n = 9) quality were included. Features of vascular pathology included atherosclerosis, vascular stiffness, and endothelial dysfunction in different vascular beds. There was evidence for an association between vascular pathology and risk of hand OA in women but not men, and between vascular pathology and risk of knee OA in both men and women. Only 2 studies examined hip OA showing no association between vascular pathology and risk of hip OA. CONCLUSION: There is evidence suggesting an association between vascular pathology and risk of hand and knee OA, with a potential causal relationship for knee OA. Based on the limited evidence, it is hard to conclude an association for hip OA. Further stronger evidence is needed to determine whether there is a causal relationship.
OBJECTIVE: Vascular pathology (changes in blood vessels) and osteoarthritis (OA) are both common chronic conditions associated with aging and obesity, but whether vascular pathology is a risk factor for OA is unclear. The aim of this study was to systematically review the evidence for an association between vascular pathology and risk of joint-specific OA. METHODS: Scopus, Ovid Medline, and EMBASE were searched from inception to February 2019. MeSH terms and keywords were used to identify studies examining the association between vascular pathology and OA. Two reviewers independently extracted the data and assessed the methodological quality. Qualitative evidence synthesis was performed. RESULTS: Fifteen studies with high (n = 3), fair (n = 3), or low (n = 9) quality were included. Features of vascular pathology included atherosclerosis, vascular stiffness, and endothelial dysfunction in different vascular beds. There was evidence for an association between vascular pathology and risk of hand OA in women but not men, and between vascular pathology and risk of knee OA in both men and women. Only 2 studies examined hip OA showing no association between vascular pathology and risk of hip OA. CONCLUSION: There is evidence suggesting an association between vascular pathology and risk of hand and knee OA, with a potential causal relationship for knee OA. Based on the limited evidence, it is hard to conclude an association for hip OA. Further stronger evidence is needed to determine whether there is a causal relationship.
Authors: Quan Zhou; Huan Sun; Jin Jia; Jun-Liang Jiang; Tao Li; Zhao-Xiang Wu; Zhong Chen Journal: Comput Math Methods Med Date: 2022-07-11 Impact factor: 2.809