Baldeep S Pabla1, Shailja C Shah1, Juan E Corral2, Douglas R Morgan3. 1. Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. 2. Division of Gastroenterology, Mayo Clinic Florida, Jacksonville, Florida. 3. Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt Ingram Cancer Center, Nashville, Tennessee; Division of Gastroenterology and Hepatology, The University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: drmorgan@uabmc.edu.
Abstract
BACKGROUND & AIMS: Gastric cancer is the leading cause of infection-related cancer death and the third-leading cause of cancer death worldwide. The effect of immigration on gastric cancer risk is not well-defined but might be helpful for screening or surveillance endeavors. We performed a systematic review and meta-analysis to define the risk of gastric cancer in immigrants from high-incidence regions to low-incidence regions (including Western Europe, Australia, Brazil, Canada, Israel, and the United States). METHODS: We searched MEDLINE and EMBASE databases, from January 1980 to January 2019, for studies that identified immigrants from high-incidence regions of gastric cancer, provided clear definitions of immigrant and reference populations, and provided sufficient data to calculate gastric cancer incidence and gastric cancer-related mortality. We performed meta-analyses of standardized incidence ratios (SIR) for first-generation immigrants from high- to low-incidence regions, stratified by immigrant generation, sex, and anatomic and histologic subtype, when data were available. RESULTS: We identified 38 cohort studies that met our inclusion criteria. All 13 studies of 21 distinct populations reported significantly increased SIRs for gastric cancer in first-generation foreign-born immigrants (men SIR range, 1.24-4.50 and women SIR range, 1.27-5.05). The pooled SIR for immigrants with all types of gastric cancer was 1.66 (95% CI, 1.52-1.80) for men and 1.83 (95% CI, 1.69-1.98) for women. Nine studies from 2 high-incidence populations (the former Soviet Union and Japan) reported an increased gastric cancer standardized mortality ratio in first-generation immigrants who migrated to regions of low incidence (former Soviet Union immigrants, 1.44-1.91 for men and 1.40-2.56 for women). CONCLUSIONS: Immigrants from regions with a high incidence of gastric cancer to regions of low incidence maintain a higher risk of gastric cancer and related mortality, based on a comprehensive systematic review and meta-analysis. Assessment of immigrant generation along with other risk factors might help identify high-risk populations for prevention and therapeutic interventions.
BACKGROUND & AIMS:Gastric cancer is the leading cause of infection-related cancer death and the third-leading cause of cancer death worldwide. The effect of immigration on gastric cancer risk is not well-defined but might be helpful for screening or surveillance endeavors. We performed a systematic review and meta-analysis to define the risk of gastric cancer in immigrants from high-incidence regions to low-incidence regions (including Western Europe, Australia, Brazil, Canada, Israel, and the United States). METHODS: We searched MEDLINE and EMBASE databases, from January 1980 to January 2019, for studies that identified immigrants from high-incidence regions of gastric cancer, provided clear definitions of immigrant and reference populations, and provided sufficient data to calculate gastric cancer incidence and gastric cancer-related mortality. We performed meta-analyses of standardized incidence ratios (SIR) for first-generation immigrants from high- to low-incidence regions, stratified by immigrant generation, sex, and anatomic and histologic subtype, when data were available. RESULTS: We identified 38 cohort studies that met our inclusion criteria. All 13 studies of 21 distinct populations reported significantly increased SIRs for gastric cancer in first-generation foreign-born immigrants (men SIR range, 1.24-4.50 and women SIR range, 1.27-5.05). The pooled SIR for immigrants with all types of gastric cancer was 1.66 (95% CI, 1.52-1.80) for men and 1.83 (95% CI, 1.69-1.98) for women. Nine studies from 2 high-incidence populations (the former Soviet Union and Japan) reported an increased gastric cancer standardized mortality ratio in first-generation immigrants who migrated to regions of low incidence (former Soviet Union immigrants, 1.44-1.91 for men and 1.40-2.56 for women). CONCLUSIONS: Immigrants from regions with a high incidence of gastric cancer to regions of low incidence maintain a higher risk of gastric cancer and related mortality, based on a comprehensive systematic review and meta-analysis. Assessment of immigrant generation along with other risk factors might help identify high-risk populations for prevention and therapeutic interventions.
Authors: Héctor Gómez-Dantés; Héctor Lamadrid-Figueroa; Lucero Cahuana-Hurtado; Omar Silverman-Retana; Pablo Montero; María Cecilia González-Robledo; Christina Fitzmaurice; Amanda Pain; Christine Allen; Daniel J Dicker; Hannah Hamavid; Alan López; Christopher Murray; Mohsen Naghavi; Rafael Lozano Journal: Salud Publica Mex Date: 2016-04
Authors: Umar Z Ikram; Johan P Mackenbach; Seeromanie Harding; Grégoire Rey; Raj S Bhopal; Enrique Regidor; Michael Rosato; Knud Juel; Karien Stronks; Anton E Kunst Journal: Eur J Epidemiol Date: 2015-09-11 Impact factor: 8.082
Authors: Anna K Miller; Gloria Tavera; Scott M Williams; Douglas R Morgan; Ricardo L Dominguez; M Constanza Camargo; Tim Waterboer; Keith T Wilson Journal: Oncogene Date: 2021-08-10 Impact factor: 9.867
Authors: Mimi C Tan; Taher Jamali; Theresa H Nguyen; Amy Galvan; Robert J Sealock; Anam Khan; Neda Zarrin-Khameh; Ashley Holloman; Ourania Kampagianni; David Henriquez Ticas; Yan Liu; Hashem B El-Serag; Aaron P Thrift Journal: Am J Gastroenterol Date: 2022-02-01 Impact factor: 12.045
Authors: Shria Kumar; Alejandro Mantero; Cindy Delgado; Barbara Dominguez; Nadine Nuchovich; David S Goldberg Journal: Ann Gastroenterol Date: 2021-06-03