H Nursun Ozcan1, Musturay Karcaaltincaba2, Emine Pektas3, H Serap Sivri4, Berna Oguz2, Ali Dursun4, Aysegul Tokatli4, Turgay Coskun4, Mithat Haliloglu2. 1. Department of Radiology, Hacettepe University School of Medicine Ankara, Turkey. Electronic address: drhnozcan@yahoo.com. 2. Department of Radiology, Hacettepe University School of Medicine Ankara, Turkey. 3. Department of Pediatrics, Division of Pediatric Metabolic Diseases, Cengiz Gokcek Children Hospital Gaziantep, Turkey. 4. Department of Pediatrics, Division of Pediatric Metabolic Diseases, Hacettepe University School of Medicine Ankara, Turkey.
Abstract
OBJECTIVE: To describe the liver imaging findings of Hereditary tyrosinemia type-1 (HT1) patients. MATERIALS AND METHODS: We report 16 patients (8 Female and 8 Male) with HT-1. Their demographic features, imaging findings and alpha feto protein (AFP) levels were recorded. Imaging features on CT and MR were evaluated for the following characteristics: contour of the liver and liver nodules. Liver nodules were categorized as; regenerative, dysplastic, fatty and malignant nodules (HCC). RESULTS: Thirteen (81%) patients had multiple liver nodules (>20) on imaging studies. Five patients (31%) had regenerative nodules, six (38%) had dysplastic nodules and ten (63%) had fatty nodules. Dysplastic nodules were encountered in two patients with HCC and in four patients without a tumor. Four patients (25%) had HCC nodule on imaging studies. Those four patients had biopsy and all of them had HCC nodule on histopathology. In the follow-up period, in one patient fatty nodules had increased in size, in one patient regenerative nodules had disappeared and in one patient dysplastic nodules had disappeared. CONCLUSIONS: Multiple fatty nodules can be seen in HT1 patients and in some patients, the regenerative and dysplastic nodules can disappear during the follow-up period.
OBJECTIVE: To describe the liver imaging findings of Hereditary tyrosinemia type-1 (HT1) patients. MATERIALS AND METHODS: We report 16 patients (8 Female and 8 Male) with HT-1. Their demographic features, imaging findings and alpha feto protein (AFP) levels were recorded. Imaging features on CT and MR were evaluated for the following characteristics: contour of the liver and liver nodules. Liver nodules were categorized as; regenerative, dysplastic, fatty and malignant nodules (HCC). RESULTS: Thirteen (81%) patients had multiple liver nodules (>20) on imaging studies. Five patients (31%) had regenerative nodules, six (38%) had dysplastic nodules and ten (63%) had fatty nodules. Dysplastic nodules were encountered in two patients with HCC and in four patients without a tumor. Four patients (25%) had HCC nodule on imaging studies. Those four patients had biopsy and all of them had HCC nodule on histopathology. In the follow-up period, in one patient fatty nodules had increased in size, in one patient regenerative nodules had disappeared and in one patientdysplastic nodules had disappeared. CONCLUSIONS: Multiple fatty nodules can be seen in HT1 patients and in some patients, the regenerative and dysplastic nodules can disappear during the follow-up period.