Georgios N Belibasakis1, Nagihan Bostanci2, Philip D Marsh3, Egija Zaura4. 1. Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden. Electronic address: george.belibasakis@ki.se. 2. Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden. 3. Department of Oral Biology, School of Dentistry, University of Leeds, UK. 4. Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, the Netherlands.
Abstract
OBJECTIVE: In the era of personalized medicine, it is imperative that oral health is integrated into this concept. The oral cavity fosters a highly individualized microbiome that has evolved to promote oral health, and which exists in a dynamic balance with the host. Microecological changes to the biology of the mouth [e.g. in the host diet and lifestyle, or status of the immune system] may drive deleterious shifts in the composition or metabolic activity of the oral microbiome ['dysbiosis']. This review aims to explore how knowledge of the oral microbiome may be utilized for personalized dentistry at the point-of-care. DESIGN: This is a comprehensive narrative review of the literature, summarizing the perspectives of the authors. RESULTS: The huge increase in recent knowledge on the ecology and microbiology of the oral cavity generated by 'OMIC' technologies may indeed be clinically translated to support patient care, in terms of prevention, monitoring, risk classification or early diagnosis. The identified clinical applications may not only include dental caries and periodontal disease, but also dental implants and orthodontics. Population-based applications may include systemic health, pregnancy and elderly populations. CONCLUSIONS: Applications of selected oral microbiome and host-related biochemical parameters [e.g. the saliva proteome] for personalized dentistry can be customized for different clinical applications or individual populations, at point-of-care hubs.
OBJECTIVE: In the era of personalized medicine, it is imperative that oral health is integrated into this concept. The oral cavity fosters a highly individualized microbiome that has evolved to promote oral health, and which exists in a dynamic balance with the host. Microecological changes to the biology of the mouth [e.g. in the host diet and lifestyle, or status of the immune system] may drive deleterious shifts in the composition or metabolic activity of the oral microbiome ['dysbiosis']. This review aims to explore how knowledge of the oral microbiome may be utilized for personalized dentistry at the point-of-care. DESIGN: This is a comprehensive narrative review of the literature, summarizing the perspectives of the authors. RESULTS: The huge increase in recent knowledge on the ecology and microbiology of the oral cavity generated by 'OMIC' technologies may indeed be clinically translated to support patient care, in terms of prevention, monitoring, risk classification or early diagnosis. The identified clinical applications may not only include dental caries and periodontal disease, but also dental implants and orthodontics. Population-based applications may include systemic health, pregnancy and elderly populations. CONCLUSIONS: Applications of selected oral microbiome and host-related biochemical parameters [e.g. the saliva proteome] for personalized dentistry can be customized for different clinical applications or individual populations, at point-of-care hubs.
Authors: Georgios N Belibasakis; Terhi Maula; Kai Bao; Mark Lindholm; Nagihan Bostanci; Jan Oscarsson; Riikka Ihalin; Anders Johansson Journal: Pathogens Date: 2019-11-06
Authors: Brandon Khor; Michael Snow; Elisa Herrman; Nicholas Ray; Kunal Mansukhani; Karan A Patel; Nasser Said-Al-Naief; Tom Maier; Curtis A Machida Journal: Microorganisms Date: 2021-02-26
Authors: Nagihan Bostanci; Maria Christine Krog; Luisa W Hugerth; Zahra Bashir; Emma Fransson; Fredrik Boulund; Georgios N Belibasakis; Kristin Wannerberger; Lars Engstrand; Henriette Svarre Nielsen; Ina Schuppe-Koistinen Journal: Front Cell Infect Microbiol Date: 2021-03-19 Impact factor: 5.293
Authors: Pune N Paqué; Christopher Herz; Daniel B Wiedemeier; Konstantinos Mitsakakis; Thomas Attin; Kai Bao; Georgios N Belibasakis; John P Hays; Joël S Jenzer; Wendy E Kaman; Michal Karpíšek; Philipp Körner; Johannes R Peham; Patrick R Schmidlin; Thomas Thurnheer; Florian J Wegehaupt; Nagihan Bostanci Journal: J Pers Med Date: 2021-03-23