Bioavailability of nanotechnology-based bioactives and nutraceuticals.

Bioaccessibility and bioavailability of some hydrophobic bioactives (e.g., carotenoids, polyphenols, fat-soluble vitamins, phytosterols and fatty acids) are limited due to their low water solubility, and in some instances low chemical stability. Nanotechnology involving nanometric (r<500nm) delivery systems, can be used to improve the solubility and thus enhance the bioaccessibility and bioavailability of hydrophobic compounds. Nanometric delivery systems, derived from food grade phospholipids and biopolymers adopt many forms, including liposomes, micelles, micro/nanoemulsions, particles, polyelectrolyte complexes, and hydrogels. The small particle sizes and customized materials used to create delivery systems confer their unique properties such as higher stability and/or resistance to enzymatic activity in the gastrointestinal tract. This chapter provides an overview of bioaccessibility and bioavailability of different classes of hydrophobic bioactive compounds, focusing on nanometric delivery systems and methods of evaluation.