Ana Pascual-Sánchez1, Cristina Jenaro2, José Manuel Montes-Rodríguez3. 1. Service of Psychiatry, University Hospital Ramón y Cajal, Ctra. Colmenar Viejo km. 9.1, 28034 Madrid, Spain. Electronic address: anapascualsan@gmail.com. 2. Faculty of Psychology/INICO, University of Salamanca, Spain. 3. Service of Psychiatry, University Hospital Ramón y Cajal, CIBERSAM, IRYCIS, University of Alcala, Madrid, Spain.
Abstract
BACKGROUND: Patients with bipolar disorder, even euthymic, could suffer an impairment in their quality of life compared to healthy controls. Since no previous systematic review and meta-analysis has been conducted, the aim of the current study is to conduct a systematic review and meta-analysis of cross-sectional case-controlled studies on quality of life in adult euthymic Bipolar Disorder patients. METHODS: A systematic review and meta-analysis that followed the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) was conducted. Major electronic databases were searched on August 2018 to assess the variables associated with quality of life in euthymic bipolar disorder patients. After selecting case-control studies, data collection, quality assessment and subsequently statistical analysis were done. RESULTS: 66 studies were finally selected for systematic review and meta-analysis. Four different quality of life instruments were used among the different studies. Effect size analysis showed that there were significant differences in quality of life outcomes between euthymic bipolar disorder patients and healthy controls (d=-0.922; SE=0.316; 95%CI=-1.541--0.303; p=.004), with lower quality of life in the euthymic patients. Furthermore, time since euthymia explained 15.62% of variability, and age of control group explained 29.6% of variability. No other moderators were statiscally significant. LIMITATIONS: The instruments used were heterogeneous. Moreover, the role of other clinical moderators could not be included due to the lack of this information in most of the articles. CONCLUSIONS: Quality of life is lower in euthymic bipolar patients than in healthy controls. However, longer time in euthymia is associated with better outcomes.
BACKGROUND:Patients with bipolar disorder, even euthymic, could suffer an impairment in their quality of life compared to healthy controls. Since no previous systematic review and meta-analysis has been conducted, the aim of the current study is to conduct a systematic review and meta-analysis of cross-sectional case-controlled studies on quality of life in adult euthymic Bipolar Disorderpatients. METHODS: A systematic review and meta-analysis that followed the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) was conducted. Major electronic databases were searched on August 2018 to assess the variables associated with quality of life in euthymic bipolar disorderpatients. After selecting case-control studies, data collection, quality assessment and subsequently statistical analysis were done. RESULTS: 66 studies were finally selected for systematic review and meta-analysis. Four different quality of life instruments were used among the different studies. Effect size analysis showed that there were significant differences in quality of life outcomes between euthymic bipolar disorderpatients and healthy controls (d=-0.922; SE=0.316; 95%CI=-1.541--0.303; p=.004), with lower quality of life in the euthymic patients. Furthermore, time since euthymia explained 15.62% of variability, and age of control group explained 29.6% of variability. No other moderators were statiscally significant. LIMITATIONS: The instruments used were heterogeneous. Moreover, the role of other clinical moderators could not be included due to the lack of this information in most of the articles. CONCLUSIONS: Quality of life is lower in euthymic bipolarpatients than in healthy controls. However, longer time in euthymia is associated with better outcomes.
Authors: Anna Wrobel; Samantha E Russell; Olivia M Dean; Sue Cotton; Michael Berk; Alyna Turner Journal: BMJ Open Date: 2021-04-29 Impact factor: 2.692
Authors: Imke Hanssen; Nicole van der Horst; Marieke Boele; Marc Lochmann van Bennekom; Eline Regeer; Anne Speckens Journal: Int J Bipolar Disord Date: 2020-11-11
Authors: Françoise Jermann; Nader Perroud; Sophie Favre; Jean-Michel Aubry; Hélène Richard-Lepouriel Journal: Qual Life Res Date: 2021-07-14 Impact factor: 4.147