V P Matei1,2, T Purnichi3, A Mihailescu4,5, R Grigoras6. 1. "Prof. Dr. Alexandru Obregia" Clinical Psychiatric Hospital, Psychiatry, 2 Department, Romania. 2. "Prof. Dr. Alexandru Obregia" Clinical Psychiatric Hospital, Neurology, Neurosurgery, Psychiatry and Child and Adolescent Psychiatry Department, Romania. 3. "Prof. Dr. Alexandru Obregia" Clinical Psychiatric Hospital, University of Medicine and Pharmacy of Craiova, Craiova, Romania. 4. "Prof. Dr. Alexandru Obregia" Clinical Psychiatric Hospital, 1 Department, "Carol Davila" University of Medicine and Pharmacy, Romania. 5. "Prof. Dr. Alexandru Obregia" Clinical Psychiatric Hospital, Complementary Sciences, Bucharest, Romania. 6. Voila Psychiatric Hospital - 1 department, Campina, Romania.
Abstract
CONTEXT: Atypical antipsychotics (AAs) are the first-line treatments for schizophrenia, schizoaffective disorder and bipolar disorder. However, they are now extensively utilized as off label in a myriad of diseases despite their frequently serious metabolic side-effects and hyperprolactinemia. OBJECTIVE: The purpose of our study was to observe long-term (one year) prolactin level change in first episode schizophrenia patients treated with one of the four AAs: olanzapine, quetiapine, amisulpride, ziprasidone. DESIGN: This study is an analysis of the prolactin level associated with the atypical antipsychotics used in European First Episode Schizophrenia Trial (EUFEST) study. SUBJECTS AND METHODS: Seventy-three first episode schizophrenia patients from the 113 patients, randomized to one of the four AAs treatment arms. Prolactin level was obtained at baseline, 6 and 12 months for all the four AAs. Analyses have been done for each antipsychotic separately for each sex. RESULTS: For the male patients neither of the four antipsychotics have been associated with a statistically significant increase of prolactin level in the entire study (p>0.05). In case of the female patients, treatment with olanzapine (p=.021) and ziprasidone (p=.005) has been associated with a decrease of prolactin level in one year compared with baseline. CONCLUSIONS: In both men and women, the administration of these four AAs is not associated with the increase of prolactin levels, moreover, in women's case, there is a reduction of prolactin values at administration of Olanzapine and Ziprasidone. These results are optimistic, suggesting that long term administration of these antipsychotics is safe regarding prolactin level.
CONTEXT: Atypical antipsychotics (AAs) are the first-line treatments for schizophrenia, schizoaffective disorder and bipolar disorder. However, they are now extensively utilized as off label in a myriad of diseases despite their frequently serious metabolic side-effects and hyperprolactinemia. OBJECTIVE: The purpose of our study was to observe long-term (one year) prolactin level change in first episode schizophrenia patients treated with one of the four AAs: olanzapine, quetiapine, amisulpride, ziprasidone. DESIGN: This study is an analysis of the prolactin level associated with the atypical antipsychotics used in European First Episode Schizophrenia Trial (EUFEST) study. SUBJECTS AND METHODS: Seventy-three first episode schizophrenia patients from the 113 patients, randomized to one of the four AAs treatment arms. Prolactin level was obtained at baseline, 6 and 12 months for all the four AAs. Analyses have been done for each antipsychotic separately for each sex. RESULTS: For the male patients neither of the four antipsychotics have been associated with a statistically significant increase of prolactin level in the entire study (p>0.05). In case of the female patients, treatment with olanzapine (p=.021) and ziprasidone (p=.005) has been associated with a decrease of prolactin level in one year compared with baseline. CONCLUSIONS: In both men and women, the administration of these four AAs is not associated with the increase of prolactin levels, moreover, in women's case, there is a reduction of prolactin values at administration of Olanzapine and Ziprasidone. These results are optimistic, suggesting that long term administration of these antipsychotics is safe regarding prolactin level.
Authors: George M Anderson; Lawrence Scahill; James T McCracken; Christopher J McDougle; Michael G Aman; Elaine Tierney; L Eugene Arnold; Andrés Martin; Liliya Katsovich; David J Posey; Bhavik Shah; Benedetto Vitiello Journal: Biol Psychiatry Date: 2006-05-30 Impact factor: 13.382