A Atanasova Boshku1, D Ivanova Panova1, B Zafirova Ivanovska2. 1. University Clinic of Gynecology and Obstetrics, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia. 2. Institute of Epidemiology and Biostatistics with Medical Informatics, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
Abstract
Adipose tissue is a major store of energy for the human body. Polycystic ovary syndrome (PCOS) patients are more prone to abnormal production of some regulatory proteins secreted from the adipose tissue. This study aims to investigate serum levels of adiponectin and their correlation with metabolic and endocrine indices in PCOS. PATIENTS AND METHODS: This study was conducted on 61 women with PCOS and 17 healthy women whose age and body mass index (BMI) were matched. Adiponectin serum levels were assessed and correlated with parameters of metabolic and hormonal disturbances. RESULTS: In PCOS women, serum levels of insulin, HOMA-IR, testosterone, LH, and LH/FSH were significantly higher, while SHBG was lower than in healthy women. Lower adiponectin was observed in both PCOS groups compared to the control group. Serum levels of adiponectin correlated inversely with BMI (r=- 0.56; p<0.001),WC(r = -0.452;p<0.001), insulin levels (r= - 0.409; p<0.001), HOMA-IR (r= -0.368; p<0.001), and free androgen index (FAI) (r= - 0.53; p<0.001). A positive correlation was found between adiponectin and LH (r= 0.35; p<0.001), LH/FSH ratio (r= 0.33; p<0.001) and SHGB (r= 0.51; p<0.001). Serum adiponectin levels are decreased in women with PCOS compared to the control group. The decrease in adiponectin concentration indicates its potential role in metabolic disorders in the pathogenesis of PCOS, as well as in the development and progression of insulin resistance in PCOS patients.
Adipose tissue is a major store of energy for the human body. Polycystic ovary syndrome (PCOS) patients are more prone to abnormal production of some regulatory proteins secreted from the adipose tissue. This study aims to investigate serum levels of adiponectin and their correlation with metabolic and endocrine indices in PCOS. PATIENTS AND METHODS: This study was conducted on 61 women with PCOS and 17 healthy women whose age and body mass index (BMI) were matched. Adiponectin serum levels were assessed and correlated with parameters of metabolic and hormonal disturbances. RESULTS: In PCOS women, serum levels of insulin, HOMA-IR, testosterone, LH, and LH/FSH were significantly higher, while SHBG was lower than in healthy women. Lower adiponectin was observed in both PCOS groups compared to the control group. Serum levels of adiponectin correlated inversely with BMI (r=- 0.56; p<0.001),WC(r = -0.452;p<0.001), insulin levels (r= - 0.409; p<0.001), HOMA-IR (r= -0.368; p<0.001), and free androgen index (FAI) (r= - 0.53; p<0.001). A positive correlation was found between adiponectin and LH (r= 0.35; p<0.001), LH/FSH ratio (r= 0.33; p<0.001) and SHGB (r= 0.51; p<0.001). Serum adiponectin levels are decreased in women with PCOS compared to the control group. The decrease in adiponectin concentration indicates its potential role in metabolic disorders in the pathogenesis of PCOS, as well as in the development and progression of insulin resistance in PCOS patients.
Authors: A Katsuki; Y Sumida; E C Gabazza; S Murashima; M Furuta; R Araki-Sasaki; Y Hori; Y Yano; Y Adachi Journal: Diabetes Care Date: 2001-02 Impact factor: 19.112
Authors: Krzysztof C Lewandowski; Konrad Szosland; Chris O'Callaghan; Bee K Tan; Harpal S Randeva; Andrzej Lewinski Journal: Mol Genet Metab Date: 2005-02-12 Impact factor: 4.797
Authors: H F Escobar-Morreale; G Villuendas; J I Botella-Carretero; F Alvarez-Blasco; R Sanchón; M Luque-Ramírez; J L San Millán Journal: Hum Reprod Date: 2006-05-04 Impact factor: 6.918
Authors: Jana Vrbíková; Katerina Dvoráková; Martin Hill; Josef Vcelák; Sona Stanická; Markéta Vanková; Daniela Srámková; Karel Vondra; Bela Bendlová; Luboslav Stárka Journal: Gynecol Obstet Invest Date: 2005-06-06 Impact factor: 2.031
Authors: Z Soyman; S Durmus; S Ates; G Simsek; V Sozer; B P Kundaktepe; D Kurtulus; R Gelisgen; V Sal; H Uzun Journal: Acta Endocrinol (Buchar) Date: 2022 Jan-Mar Impact factor: 1.104