F Ekinci1, U E Soyaltin1, Y B Kutbay2, H Y Yaşar3, T Demirci Yıldırım1, H Akar1. 1. Tepecik Training and Research Hospital - Dept. of Internal Medicine, Izmir, Turkey. 2. Tepecik Training and Research Hospital - Dept. of Genetics, Izmir, Turkey. 3. Tepecik Training and Research Hospital - Dept. of Endocrine, Izmir, Turkey.
Abstract
OBJECTIVE: Adrenal incidentaloma are lesions which are stated incidentally by imaging methods when there is no suspicion of any disease in adrenal gland. Inappropriate Jak2 signaling causes some solid and hematological malignancies. But the Jak2 mutation has not been previously evaluated with regard to adrenal tumors. In this study, we aimed to positivity of the Jak2 mutation in patients with non functioning adrenal incidentaloma (NFAI). METHODS: 45 (38 female-7 male) patients, who were followed due to NFAI at Tepecik Training and Research Hospital, Department of Endocrinology and Internal Medicine between February 2014 and March 2015, and 45 (31 female-14 male) healthy controls were included in the study. RESULTS: The average age was 54.02±11.7 years and 38 patients were female, 7 were men. All patients underwent the following analyses for excluding a functioning adrenal mass, overnight dexamethasone suppression test, 24 hour urinary metanephrine and normetanephrine, plasma aldosterone/ renin activity ratio. Jak2 mutation of the patients who were diagnosed as NFAI was all negative. CONCLUSION: We could not identify the JAK2 gene mutation positivity in any sample. Since other possible mechanisms may throw fresh light on the etiology of adrenal incidentaloma, further clinical studies are needed on this subject.
OBJECTIVE: Adrenal incidentaloma are lesions which are stated incidentally by imaging methods when there is no suspicion of any disease in adrenal gland. Inappropriate Jak2 signaling causes some solid and hematological malignancies. But the Jak2 mutation has not been previously evaluated with regard to adrenal tumors. In this study, we aimed to positivity of the Jak2 mutation in patients with non functioning adrenal incidentaloma (NFAI). METHODS: 45 (38 female-7 male) patients, who were followed due to NFAI at Tepecik Training and Research Hospital, Department of Endocrinology and Internal Medicine between February 2014 and March 2015, and 45 (31 female-14 male) healthy controls were included in the study. RESULTS: The average age was 54.02±11.7 years and 38 patients were female, 7 were men. All patients underwent the following analyses for excluding a functioning adrenal mass, overnight dexamethasone suppression test, 24 hour urinary metanephrine and normetanephrine, plasma aldosterone/ renin activity ratio. Jak2 mutation of the patients who were diagnosed as NFAI was all negative. CONCLUSION: We could not identify the JAK2 gene mutation positivity in any sample. Since other possible mechanisms may throw fresh light on the etiology of adrenal incidentaloma, further clinical studies are needed on this subject.
Authors: Janae Strickland; Stephen McIlmoil; Brice J Williams; Dennis C Seager; James P Porter; Allan M Judd Journal: Steroids Date: 2017-01-04 Impact factor: 2.668
Authors: Tomasz Bednarczuk; Marek Bolanowski; Krzysztof Sworczak; Barbara Górnicka; Andrzej Cieszanowski; Maciej Otto; Urszula Ambroziak; Janusz Pachucki; Eliza Kubicka; Anna Babińska; Łukasz Koperski; Andrzej Januszewicz; Aleksander Prejbisz; Maria Górska; Barbara Jarząb; Alicja Hubalewska-Dydejczyk; Piotr Glinicki; Marek Ruchała; Anna Kasperlik-Załuska Journal: Endokrynol Pol Date: 2016 Impact factor: 1.582