A R Çimen1, E T Cerit1, O T Iyidir1, R Karakus2, B B Uyar3, F B Toruner1, N Cakir1, M Arslan1. 1. Gazi University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey. 2. Gazi University Faculty of Medicine, Department of Immunology, Ankara, Turkey. 3. Gazi University Faculty of Medicine, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkey.
Abstract
INTRODUCTION: Our aim was to investigate the relationship between serum omentin-1 levels and endothelial dysfunction in obese patients. MATERIAL AND METHODS: We evaluated 50 obese patients, and age/gender matched 45 healthy non-obese subjects as controls. Oral glucose tolerance test, lipid parameters, uric acid levels, homeostatic model assessment-insulin resistance (HOMA-IR) index, serum omentin-1 levels and flow mediated dilatation (FMD) % were measured in all subjects. Body compositions were analyzed with bioelectrical impedance method using a Tanita Body Composition Analyzer and ViScan. RESULTS: Serum omentin-1 levels were found significantly lower in obese population compared to the control subjects. FMD response was significantly decreased in obese population. There was a significant positive correlation between serum omentin-1 levels and FMD response (r=0.359, p<0.001). Serum omentin-1 levels were negatively correlated with body mass index (BMI), waist circumference, total fat percentage, visceral fat, fasting insulin and HOMA-IR index. CONCLUSION: Lower serum omentin-1 levels and decreased FMD response may be an early marker of endothelial dysfunction in obese patients.
INTRODUCTION: Our aim was to investigate the relationship between serum omentin-1 levels and endothelial dysfunction in obese patients. MATERIAL AND METHODS: We evaluated 50 obese patients, and age/gender matched 45 healthy non-obese subjects as controls. Oral glucose tolerance test, lipid parameters, uric acid levels, homeostatic model assessment-insulin resistance (HOMA-IR) index, serum omentin-1 levels and flow mediated dilatation (FMD) % were measured in all subjects. Body compositions were analyzed with bioelectrical impedance method using a Tanita Body Composition Analyzer and ViScan. RESULTS: Serum omentin-1 levels were found significantly lower in obese population compared to the control subjects. FMD response was significantly decreased in obese population. There was a significant positive correlation between serum omentin-1 levels and FMD response (r=0.359, p<0.001). Serum omentin-1 levels were negatively correlated with body mass index (BMI), waist circumference, total fat percentage, visceral fat, fasting insulin and HOMA-IR index. CONCLUSION: Lower serum omentin-1 levels and decreased FMD response may be an early marker of endothelial dysfunction in obese patients.
Authors: E L Thomas; A L Collins; J McCarthy; J Fitzpatrick; G Durighel; A P Goldstone; J D Bell Journal: Eur J Clin Nutr Date: 2010-03-31 Impact factor: 4.016
Authors: Celia M de Souza Batista; Rong-Ze Yang; Mi-Jeong Lee; Nicole M Glynn; Dao-Zhan Yu; Jessica Pray; Kelechi Ndubuizu; Susheel Patil; Alan Schwartz; Mark Kligman; Susan K Fried; Da-Wei Gong; Alan R Shuldiner; Toni I Pollin; John C McLenithan Journal: Diabetes Date: 2007-02-28 Impact factor: 9.461
Authors: Rong-Ze Yang; Mi-Jeong Lee; Hong Hu; Jessica Pray; Hai-Bin Wu; Barbara C Hansen; Alan R Shuldiner; Susan K Fried; John C McLenithan; Da-Wei Gong Journal: Am J Physiol Endocrinol Metab Date: 2006-03-10 Impact factor: 4.310
Authors: V Soldat-Stankovic; S Popovic Pejicic; S Stankovic; J Jovanic; J Bjekic-Macut; S Livadas; S Ognjanovic; G Mastorakos; D Micic; D Macut Journal: Acta Endocrinol (Buchar) Date: 2021 Apr-Jun Impact factor: 0.877