H Diri1, E F Sener2, F Bayram1, M Dundar3, Y Simsek1, O Baspinar4, G Zararsiz5. 1. Erciyes University Medical School, Division of Endocrinology, Kayseri, Turkey. 2. Erciyes University Medical School, Dept. of Medical Biology, Kayseri, Turkey. 3. Erciyes University Medical School, Dept. of Medical Genetics, Kayseri, Turkey. 4. Erciyes University Medical School, Dept. of Internal Diseases, Kayseri, Turkey. 5. Erciyes University Medical School, Dept. of Biostatistics, Kayseri, Turkey.
Abstract
INTRODUCTION: Genetic disorders associated with the development of the pituitary gland and cranial bones may cause a genetic tendency toward Sheehan's syndrome (SS). Our aim in this study was to investigate expression disorders in the genes responsible for the development of the pituitary gland and cranial bones in patients with SS. MATERIALS AND METHODS: Forty-four patients who were previously diagnosed with SS and 43 healthy women were compared in terms of the mean expression values of genes including the prophet of PIT-1 (PROP1), HESX homeobox 1 (HESX1), POU class 1 homeobox 1 (POU1F1), LIM homeobox 3 (LHX3), LHX4, glioma-associated oncogene homolog 2 (GLI2), orthodenticle homeobox 2 (OTX2), SIX homeobox 3 (SIX3), SIX6, T-box transcription factor 19 (TBX19), transducin-like enhancer protein 1 (TLE1), TLE3, distal-less homeobox 2 (DLX2), DLX5, MSH homeobox 2 (MSX2), and paired box 3 (PAX3). RESULTS: The mean expression values of the HESX1, TLE1, TLE3, and MSX2 genes were significantly different in the SS group from the healthy control group, while the mean expression values of the remaining genes were similar. CONCLUSION: The present study concludes that abnormal expressions of HESX1, TLE1, TLE3, and MSX2 genes may cause a genetic predisposition to the development of SS.
INTRODUCTION: Genetic disorders associated with the development of the pituitary gland and cranial bones may cause a genetic tendency toward Sheehan's syndrome (SS). Our aim in this study was to investigate expression disorders in the genes responsible for the development of the pituitary gland and cranial bones in patients with SS. MATERIALS AND METHODS: Forty-four patients who were previously diagnosed with SS and 43 healthy women were compared in terms of the mean expression values of genes including the prophet of PIT-1 (PROP1), HESX homeobox 1 (HESX1), POU class 1 homeobox 1 (POU1F1), LIM homeobox 3 (LHX3), LHX4, glioma-associated oncogene homolog 2 (GLI2), orthodenticle homeobox 2 (OTX2), SIX homeobox 3 (SIX3), SIX6, T-box transcription factor 19 (TBX19), transducin-like enhancer protein 1 (TLE1), TLE3, distal-less homeobox 2 (DLX2), DLX5, MSH homeobox 2 (MSX2), and paired box 3 (PAX3). RESULTS: The mean expression values of the HESX1, TLE1, TLE3, and MSX2 genes were significantly different in the SS group from the healthy control group, while the mean expression values of the remaining genes were similar. CONCLUSION: The present study concludes that abnormal expressions of HESX1, TLE1, TLE3, and MSX2 genes may cause a genetic predisposition to the development of SS.
Entities:
Keywords:
Sheehan’s syndrome; etiopathogenesis; genetic; pituitary development
Authors: R Abs; B A Bengtsson; E Hernberg-Stâhl; J P Monson; J P Tauber; P Wilton; C Wüster Journal: Clin Endocrinol (Oxf) Date: 1999-06 Impact factor: 3.478
Authors: Kim McLennan; Yvette Jeske; Andrew Cotterill; David Cowley; James Penfold; Tim Jones; Neville Howard; Michael Thomsett; Catherine Choong Journal: Clin Endocrinol (Oxf) Date: 2003-06 Impact factor: 3.478