Literature DB >> 31149112

ORBITAL PSEUDOTUMOR CAN MIMIC GRAVES' OPHTHALMOPATHY.

M Stanciu1, F L Popa1, I G Totoian1, L G Bera1.   

Abstract

CONTEXT: Orbital pseudotumor (OP) is a benign inflammatory process of the orbit with a large polymorphous lymphoid infiltrate, associated with fibrosis in variable amounts, localized or diffuse. Graves' ophthalmopathy (GO) is the most common cause of proptosis, unilateral or bilateral. CASE REPORT: We report a patient with unilateral proptosis who was initially treated with antithyroid drugs for an euthyroid Graves disease, but the extension of the investigation infirmed this. The MRI findings (inflammation of fat, muscle and the left lacrimal gland) in conjunction with the biopsy infirmed the initial diagnostic and confirmed the OP.
CONCLUSIONS: Orbital pseudotumor is a rare disorder that can image and clinically mimics some inflammatory disease especialy Graves' ophthalmopathy. Orbital MRI represents the most important test for diagnostic. A negative TRAb in euthyroid cases of proptosis can be a serious starting point for investigating an OP.

Entities:  

Keywords:  Graves’ ophtalmopathy; MRI; TRAb; differential diagnosis; orbital pseudotumor

Year:  2016        PMID: 31149112      PMCID: PMC6535257          DOI: 10.4183/aeb.2016.344

Source DB:  PubMed          Journal:  Acta Endocrinol (Buchar)        ISSN: 1841-0987            Impact factor:   0.877


  13 in total

Review 1.  Pseudotumor of the orbit. Clinical, pathologic, and radiologic evaluation.

Authors:  A L Weber; L V Romo; N R Sabates
Journal:  Radiol Clin North Am       Date:  1999-01       Impact factor: 2.303

Review 2.  Inflammatory pseudotumor.

Authors:  Lakshmana Das Narla; Beverley Newman; Stephanie S Spottswood; Shireesha Narla; Rajasekhar Kolli
Journal:  Radiographics       Date:  2003 May-Jun       Impact factor: 5.333

Review 3.  Inflammatory pseudotumor of the cavernous sinus and skull base.

Authors:  Todd McCall; Daniel R Fassett; George Lyons; William T Couldwell
Journal:  Neurosurg Rev       Date:  2006-03-25       Impact factor: 3.042

Review 4.  Clinical practice. Graves' ophthalmopathy.

Authors:  Luigi Bartalena; Maria Laura Tanda
Journal:  N Engl J Med       Date:  2009-03-05       Impact factor: 91.245

Review 5.  Graves' ophthalmopathy.

Authors:  Rebecca S Bahn
Journal:  N Engl J Med       Date:  2010-02-25       Impact factor: 91.245

6.  Orbital pseudotumor: a differential diagnosis of Graves' ophthalmopathy.

Authors:  Luciana Souza Cruz Caminha; Elisa Rebelo Pinto; Priscila Alves Medeiros de Sousa; Ricardo Andrade Oliveira; Flavia Lucia Conceiçao; Mario Vaisman
Journal:  Arq Bras Endocrinol Metabol       Date:  2011-02

Review 7.  Orbital inflammatory pseudotumors: etiology, differential diagnosis, and management.

Authors:  Gabriela M Espinoza
Journal:  Curr Rheumatol Rep       Date:  2010-12       Impact factor: 4.592

8.  Orbital pseudotumor: distinct diagnostic features and management.

Authors:  Imtiaz A Chaudhry; Farrukh A Shamsi; Yonca O Arat; Fenwick C Riley
Journal:  Middle East Afr J Ophthalmol       Date:  2008-01

9.  Idiopathic orbital inflammation: distribution, clinical features, and treatment outcome.

Authors:  Sonia J Ahn Yuen; Peter A D Rubin
Journal:  Arch Ophthalmol       Date:  2003-04

10.  Orbital pseudotumor.

Authors:  Muqtasid A Kamili; Ali G; Ishrat H Dar; Showkat H Dar; Hardeep Singh Wazir; Tariq Qureishi
Journal:  Oman J Ophthalmol       Date:  2009-05
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