I Parepa1, L Mazilu2, A Suceveanu2, C Voinea2, I Tica3. 1. "Ovidius" University of Constanta, Faculty of Medicine - Constanta, Romania. 2. Cardiology Department, Constanta, Romania. 3. Medical Department, Constanta, Romania.
Abstract
INTRODUCTION: Heart failure and dilated cardiomyopathy (DCM) in adults are rarely caused by hypoparathyroidism induced hypocalcemia. CASE REPORT: Female patient, 40 years old, diabetic, with previous history of thyroidectomy for Graves' disease, was hospitalized for syncope and symptoms of heart failure. ECG revealed sinus tachycardia, long QT, negative T from V1 up to V4. Chest X-ray, cardiac ultrasound and contrast cardiac MRI confirmed dilated left chambers, severe systolic dysfunction of the left ventricle (left ventricle ejection fraction=15%) due to diffuse hypokinesia and restrictive type of diastolic dysfunction. Patient status insignificantly improved with specific heart failure depletion treatment but important signs of hypocalcemia occurred. Low levels of total and ionic serum calcium were detected (total serum calcium 3.6 mg/dL, ionic calcium=2.2 mg/dL) along with low serum levels of parathormone (10 pg/mL) and high level of phosphatemia (6.4 mg/dL). After one month of parenteral treatment with calcium and oral vitamin D, hypocalcemic signs disappeared and heart failure significantly improved. CONCLUSION: This rare adult condition is refractory to heart failure conventional therapy but promptly responds to restoration of normocalcemia. It is important to be aware of this pathophysiological setting, in order to treat it correctly.
INTRODUCTION: Heart failure and dilated cardiomyopathy (DCM) in adults are rarely caused by hypoparathyroidism induced hypocalcemia. CASE REPORT: Female patient, 40 years old, diabetic, with previous history of thyroidectomy for Graves' disease, was hospitalized for syncope and symptoms of heart failure. ECG revealed sinus tachycardia, long QT, negative T from V1 up to V4. Chest X-ray, cardiac ultrasound and contrast cardiac MRI confirmed dilated left chambers, severe systolic dysfunction of the left ventricle (left ventricle ejection fraction=15%) due to diffuse hypokinesia and restrictive type of diastolic dysfunction. Patient status insignificantly improved with specific heart failure depletion treatment but important signs of hypocalcemia occurred. Low levels of total and ionic serum calcium were detected (total serum calcium 3.6 mg/dL, ionic calcium=2.2 mg/dL) along with low serum levels of parathormone (10 pg/mL) and high level of phosphatemia (6.4 mg/dL). After one month of parenteral treatment with calcium and oral vitamin D, hypocalcemic signs disappeared and heart failure significantly improved. CONCLUSION: This rare adult condition is refractory to heart failure conventional therapy but promptly responds to restoration of normocalcemia. It is important to be aware of this pathophysiological setting, in order to treat it correctly.
Authors: John P Bilezikian; Aliya Khan; John T Potts; Maria Luisa Brandi; Bart L Clarke; Dolores Shoback; Harald Jüppner; Pierre D'Amour; John Fox; Lars Rejnmark; Leif Mosekilde; Mishaela R Rubin; David Dempster; Rachel Gafni; Michael T Collins; Jim Sliney; James Sanders Journal: J Bone Miner Res Date: 2011-10 Impact factor: 6.741
Authors: Rakesh Gopinathannair; Susan P Etheridge; Francis E Marchlinski; Francis G Spinale; Dhanunjaya Lakkireddy; Brian Olshansky Journal: J Am Coll Cardiol Date: 2015-10-13 Impact factor: 24.094
Authors: Thomas C Sauter; Gregor Lindner; Sufian S Ahmad; Alexander Benedikt Leichtle; Georg-Martin Fiedler; Aristomenis K Exadaktylos; Dominik G Haider Journal: PLoS One Date: 2015-07-14 Impact factor: 3.240
Authors: Brunella Capaldo; Procolo Di Bonito; Michele Iaccarino; Mary J Roman; Elisa T Lee; Richard B Devereux; Gabriele Riccardi; Barbara V Howard; Giovanni de Simone Journal: Diabetes Care Date: 2012-12-05 Impact factor: 19.112
Authors: H Ozisik; B S Yürekli; R Tuncel; N Ozdemir; M Baklaci; O Ekmekci; F Saygili Journal: Acta Endocrinol (Buchar) Date: 2020 Jan-Mar Impact factor: 0.877