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Literature DB >> 31148512

The role of DNA methylation in thermogenic adipose biology.

Abstract

The two types of thermogenic fat cells, beige and brown adipocytes, play a significant role in regulating energy homeostasis. Their development and thermogenesis are tightly regulated by dynamic epigenetic mechanisms, which could potentially be targeted to treat metabolic disorders such as obesity. However, we are just beginning to catalog and understand these dynamic changes. In this review, we will discuss the current understanding of the role of DNA (de)methylation events in beige and brown adipose biology in order to highlight the holes in our knowledge and to point the way forward for future studies.

Entities: Disease

Keywords: DNA methylation; Epigenetics; beige adipocytes; brown adipocytes; obesity; type 2 diabetes

Mesh：

Year: 2019 PMID： 31148512 PMCID： PMC6691979 DOI： 10.1080/15592294.2019.1625670

Source DB: PubMed Journal: Epigenetics ISSN： 1559-2294 Impact factor: 4.528

65 in total

1. Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.

Authors: L F Michael; Z Wu; R B Cheatham; P Puigserver; G Adelmant; J J Lehman; D P Kelly; B M Spiegelman
Journal: Proc Natl Acad Sci U S A Date: 2001-03-13 Impact factor: 11.205

Review 2. Brown adipose tissue: function and physiological significance.

Authors: Barbara Cannon; Jan Nedergaard
Journal: Physiol Rev Date: 2004-01 Impact factor: 37.312

3. Sequential changes in genome-wide DNA methylation status during adipocyte differentiation.

Authors: Hideki Sakamoto; Yasushi Kogo; Jun Ohgane; Naka Hattori; Shintaro Yagi; Satoshi Tanaka; Kunio Shiota
Journal: Biochem Biophys Res Commun Date: 2007-12-04 Impact factor: 3.575

4. Cell type-specific methylation profiles occurring disproportionately in CpG-less regions that delineate developmental similarity.

Authors: Hideki Sakamoto; Masako Suzuki; Tetsuya Abe; Tohru Hosoyama; Emi Himeno; Satoshi Tanaka; John M Greally; Naka Hattori; Shintaro Yagi; Kunio Shiota
Journal: Genes Cells Date: 2007-10 Impact factor: 1.891

The role of DNA methylation in thermogenic adipose biology.

1. Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.

Review 2. Brown adipose tissue: function and physiological significance.

3. Sequential changes in genome-wide DNA methylation status during adipocyte differentiation.

4. Cell type-specific methylation profiles occurring disproportionately in CpG-less regions that delineate developmental similarity.

5. Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: role of the BMP-4 gene.

6. Epigenetic inheritance at the agouti locus in the mouse.

Review 7. beta(3)-Adrenoceptor agonists: potential, pitfalls and progress.

Review 8. Unexpected evidence for active brown adipose tissue in adult humans.

Review 9. Gene expression in humans with diabetes and prediabetes: what have we learned about diabetes pathophysiology?

10. Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region.

Review 1. Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential.