Literature DB >> 31148013

In Situ Vaccination of Tumors Using Plant Viral Nanoparticles.

Abner A Murray1, Mee Rie Sheen2,3,4, Frank A Veliz5, Steven N Fiering2,3, Nicole F Steinmetz6,7,8,9,10.   

Abstract

Viral nanoparticles are self-assembling units that are being developed and applied for a variety of applications. While most clinical uses involve animal viruses, a plant-derived virus, cowpea mosaic virus (CPMV) has been shown to have antitumor properties in mice when applied as in situ vaccine. Here we describe the production and characterization of CPMV and its use as in situ vaccines in the context of cancer. Subsequent analyses to obtain efficacy or mechanistic data are also detailed.

Entities:  

Keywords:  B16F10; Cowpea mosaic virus (CPMV); Cytokine; Flow cytometry; Immunotherapy; In situ vaccine; Luminex multiplex; Melanoma

Mesh：

Substances：

Year:  2019        PMID： 31148013      PMCID： PMC7302950          DOI： 10.1007/978-1-4939-9516-5_10

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  1 in total

1.  In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer.

Authors:  P H Lizotte; A M Wen; M R Sheen; J Fields; P Rojanasopondist; N F Steinmetz; S Fiering
Journal:  Nat Nanotechnol       Date:  2015-12-21       Impact factor: 39.213
  1 in total
  5 in total

1.  Active Microneedle Administration of Plant Virus Nanoparticles for Cancer in situ Vaccination Improves Immunotherapeutic Efficacy.

Authors:  Christine E Boone; Chao Wang; Miguel Angel Lopez-Ramirez; Veronique Beiss; Sourabh Shukla; Paul L Chariou; Daniel Kupor; Ricardo Rueda; Joseph Wang; Nicole F Steinmetz
Journal:  ACS Appl Nano Mater       Date:  2020-08-07

2.  Inactivated Cowpea Mosaic Virus in Combination with OX40 Agonist Primes Potent Antitumor Immunity in a Bilateral Melanoma Mouse Model.

Authors:  Edward C Koellhoffer; Chenkai Mao; Veronique Beiss; Lu Wang; Steven N Fiering; Christine E Boone; Nicole F Steinmetz
Journal:  Mol Pharm       Date:  2022-01-03       Impact factor: 5.364

3.  Remission-Stage Ovarian Cancer Cell Vaccine with Cowpea Mosaic Virus Adjuvant Prevents Tumor Growth.

Authors:  Courtney T Stump; Gregory Ho; Chenkai Mao; Frank A Veliz; Veronique Beiss; Jennifer Fields; Nicole F Steinmetz; Steven Fiering
Journal:  Cancers (Basel)       Date:  2021-02-05       Impact factor: 6.639

4.  Platform for Active Vaccine Formulation Using a Two-Mode Enhancement Mechanism of Epitope Presentation by Pickering Emulsion.

Authors:  Guy Mechrez; Karthik Ananth Mani; Abhijit Saha; Oded Lachman; Neta Luria; Ori Molad; Liliya Kotliarevski; Einat Zelinger; Elisheva Smith; Noga Yaakov; Dalia Shabashov Stone; Meital Reches; Aviv Dombrovsky
Journal:  ACS Appl Bio Mater       Date:  2022-08-01

5.  Evaluation of cell surface reactive immuno-adjuvant in combination with immunogenic cell death inducing drug for in situ chemo-immunotherapy.

Authors:  Adam A Walters; Julie Tzu-Wen Wang; Khuloud T Al-Jamal
Journal:  J Control Release       Date:  2020-03-31       Impact factor: 9.776
  5 in total

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