Literature DB >> 31147936

A SIINFEKL-Based System to Measure MHC Class I Antigen Presentation Efficiency and Kinetics.

Devin Dersh1, Jonathan W Yewdell1, Jiajie Wei2,3.   

Abstract

Antigen presentation by classical MHC class I molecules to CD8+ T cells is a central aspect of the adaptive immune response. Here, we describe methods to monitor antigen presentation using the model ovalbumin Kb-binding peptide, SIINFEKL. SIINFEKL genetically incorporated into viral or cellular source proteins can be used to precisely probe various aspects of antigen presentation, including the kinetics of peptide generation, MHC class I surface stability, and presentation efficiency following pharmacological and genetic manipulations including genome wide and high throughput drug screening.

Entities:  

Keywords:  DRiPs; H-2Kb; MHC class I; MHC-I; SIINFEKL; SL8

Mesh：

Substances：

Year:  2019        PMID： 31147936      PMCID： PMC6661116          DOI： 10.1007/978-1-4939-9450-2_9

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  18 in total

1.  Dissecting the multifactorial causes of immunodominance in class I-restricted T cell responses to viruses.

Authors:  W Chen; L C Antón; J R Bennink; J W Yewdell
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Authors:  M Del Val; H J Schlicht; T Ruppert; M J Reddehase; U H Koszinowski
Journal:  Cell       Date:  1991-09-20       Impact factor: 41.582

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Authors:  J W Yewdell; L C Antón; J R Bennink
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