OBJECTIVE: The objective of this study was to evaluate the utility of frozen section (FS) in detecting occult nodal metastasis in cN0 OSCC and its impact on regional failure and survival. MATERIALS AND METHODS: Clinical records of patients of OSCC operated from January 2013 to December 2014 were retrospectively reviewed. These patients were divided into two groups-Group A comprised of patients who underwent selective neck dissection (SND) (level III/IV) and FS based completion (level IV ± V); Group B included patients who underwent SND I-III/IV without FS. The sensitivity and specificity of FS in detecting occult metastasis was calculated. The regional failure rates and overall survival (OS) between the two groups were compared. RESULTS: The sensitivity, specificity, PPV (positive predictive value) and NPV (negative predictive value) of FS in detecting occult metastasis were 64.06%, 100%, 100%, and 92.15%, respectively. There was no significant difference in regional failure rates (p = 0.219) and OS (p = 0.08) between the two groups. CONCLUSION: FS has a poor sensitivity in detecting occult nodal metastasis. FS-guided neck dissection does not have a significant impact in reducing regional failure or improving OS in clinically node-negative neck in oral cavity carcinomas.
OBJECTIVE: The objective of this study was to evaluate the utility of frozen section (FS) in detecting occult nodal metastasis in cN0 OSCC and its impact on regional failure and survival. MATERIALS AND METHODS: Clinical records of patients of OSCC operated from January 2013 to December 2014 were retrospectively reviewed. These patients were divided into two groups-Group A comprised of patients who underwent selective neck dissection (SND) (level III/IV) and FS based completion (level IV ± V); Group B included patients who underwent SND I-III/IV without FS. The sensitivity and specificity of FS in detecting occult metastasis was calculated. The regional failure rates and overall survival (OS) between the two groups were compared. RESULTS: The sensitivity, specificity, PPV (positive predictive value) and NPV (negative predictive value) of FS in detecting occult metastasis were 64.06%, 100%, 100%, and 92.15%, respectively. There was no significant difference in regional failure rates (p = 0.219) and OS (p = 0.08) between the two groups. CONCLUSION: FS has a poor sensitivity in detecting occult nodal metastasis. FS-guided neck dissection does not have a significant impact in reducing regional failure or improving OS in clinically node-negative neck in oral cavity carcinomas.
Authors: Clare Schilling; Sandro J Stoeckli; Stephan K Haerle; Martina A Broglie; Gerhard F Huber; Jens Ahm Sorensen; Vivi Bakholdt; Annelise Krogdahl; Christian von Buchwald; Anders Bilde; Lars R Sebbesen; Edward Odell; Benjamin Gurney; Michael O'Doherty; Remco de Bree; Elisabeth Bloemena; Geke B Flach; Pedro M Villarreal; Manuel Florentino Fresno Forcelledo; Luis Manuel Junquera Gutiérrez; Julio Alvarez Amézaga; Luis Barbier; Joseba Santamaría-Zuazua; Augusto Moreira; Manuel Jacome; Maurizio Giovanni Vigili; Siavash Rahimi; Girolamo Tartaglione; Georges Lawson; Marie-Cecile Nollevaux; Cesare Grandi; Davide Donner; Emma Bragantini; Didier Dequanter; Philippe Lothaire; Tito Poli; Enrico M Silini; Erinco Sesenna; Giles Dolivet; Romina Mastronicola; Agnes Leroux; Isabel Sassoon; Philip Sloan; Mark McGurk Journal: Eur J Cancer Date: 2015-11-18 Impact factor: 9.162
Authors: Chuan Bin Guo; Zhien Feng; Jian Guo Zhang; Xin Peng; Zhi Gang Cai; Chi Mao; Yi Zhang; Guang Yan Yu; Jian Nan Li; Li Xuan Niu Journal: J Craniomaxillofac Surg Date: 2014-08-06 Impact factor: 2.078