P Bertuccio1, G Alicandro2, M Malvezzi3, G Carioli3, P Boffetta4, F Levi5, C La Vecchia6, E Negri1. 1. Departments of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milan. 2. Clinical Sciences and Community Health, Università degli Studi di Milano, Milan; Directorate for Social Statistics and Population Census, Italian National Institute of Statistics (ISTAT), Rome, Italy. 3. Clinical Sciences and Community Health, Università degli Studi di Milano, Milan. 4. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. 5. Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland. 6. Clinical Sciences and Community Health, Università degli Studi di Milano, Milan. Electronic address: carlo.lavecchia@unimi.it.
Abstract
BACKGROUND: Cancer mortality in Europe has been decreasing since the late 1980s or 1990s in some countries with different patterns in many areas. In this study, we updated trends in cancer mortality in Europe. MATERIALS AND METHODS: We extracted data from the World Health Organization mortality database for 24 cancer sites, 36 European countries and the European Union (EU) as a whole over the 1990-2017 period. We computed age-standardized death rates per 100 000 person-years, and we carried out a joinpoint regression analysis of mortality trends from all cancers and selected major neoplasms. The estimated annual percent change (APC) for each identified linear segment, and the weighted average APC (AAPC) over the entire study period were provided as summary measures of the changes in rates over the time period. RESULTS: In 2015, the age-standardized mortality rates from all cancers in the EU were 137.5 deaths per 100 000 in men and 85.7 in women. Eastern European countries showed the highest rates with values over 150 deaths per 100 000 in men and over 100 deaths per 100 000 in women. Mortality from all cancers in the EU declined annually by 1.5% in men since 2006 and by 0.8% in women since 2007. Most cancer sites showed decreasing trends, with steady declines over the whole period for cancers of stomach, intestines, lung in men, breast and prostate. Unfavourable mortality trends persisted for cancers of liver, lung in women, pancreas, besides skin and kidney in men. CONCLUSIONS: The downward trends in total cancer mortality in Europe still continue over the last decade. However, the trends were less favourable in most eastern European countries. Tobacco control in men (but not in women), improvements in diagnosis and therapy were the main underlying factors of these trends.
BACKGROUND:Cancer mortality in Europe has been decreasing since the late 1980s or 1990s in some countries with different patterns in many areas. In this study, we updated trends in cancer mortality in Europe. MATERIALS AND METHODS: We extracted data from the World Health Organization mortality database for 24 cancer sites, 36 European countries and the European Union (EU) as a whole over the 1990-2017 period. We computed age-standardized death rates per 100 000 person-years, and we carried out a joinpoint regression analysis of mortality trends from all cancers and selected major neoplasms. The estimated annual percent change (APC) for each identified linear segment, and the weighted average APC (AAPC) over the entire study period were provided as summary measures of the changes in rates over the time period. RESULTS: In 2015, the age-standardized mortality rates from all cancers in the EU were 137.5 deaths per 100 000 in men and 85.7 in women. Eastern European countries showed the highest rates with values over 150 deaths per 100 000 in men and over 100 deaths per 100 000 in women. Mortality from all cancers in the EU declined annually by 1.5% in men since 2006 and by 0.8% in women since 2007. Most cancer sites showed decreasing trends, with steady declines over the whole period for cancers of stomach, intestines, lung in men, breast and prostate. Unfavourable mortality trends persisted for cancers of liver, lung in women, pancreas, besides skin and kidney in men. CONCLUSIONS: The downward trends in total cancer mortality in Europe still continue over the last decade. However, the trends were less favourable in most eastern European countries. Tobacco control in men (but not in women), improvements in diagnosis and therapy were the main underlying factors of these trends.
Authors: Ida Oberhauser; Jasmin Zeindler; Mathilde Ritter; Jeremy Levy; Giacomo Montagna; Robert Mechera; Savas Deniz Soysal; Liliana Castrezana López; Veronica D'Amico; Elisabeth Artemis Kappos; Fabienne Dominique Schwab; Madleina Müller; Christian Kurzeder; Martin Haug; Walter Paul Weber Journal: Breast Care (Basel) Date: 2020-11-25 Impact factor: 2.860
Authors: Greta Carioli; Paola Bertuccio; Fabio Levi; Paolo Boffetta; Eva Negri; Carlo La Vecchia; Matteo Malvezzi Journal: Int J Environ Res Public Health Date: 2020-07-23 Impact factor: 3.390
Authors: H Bozhar; M McKee; T Spadea; P Veerus; S Heinävaara; A Anttila; C Senore; N Zielonke; I M C M de Kok; N T van Ravesteyn; I Lansdorp-Vogelaar; H J de Koning; E A M Heijnsdijk Journal: Prev Med Rep Date: 2022-02-08