Claire Carette1, Rachel Levy2, Florence Eustache3, Gabriel Baron4, Muriel Coupaye5, Simon Msika6, Christophe Barrat7, Régis Cohen8, Jean-Marc Catheline8, Florence Brugnon9, Karem Slim10, Charles Barsamian11, Jean-Marc Chevallier12, Marion Bretault13, Jean-Luc Bouillot14, Jean-Philippe Antignac15, Claire Rives-Lange11, Philippe Ravaud4, Sébastien Czernichow16. 1. Hôpital Européen Georges Pompidou, Service de Nutrition, Centre Spécialisé Obésité (CSO) Ile-de-France Sud, APHP, Université Paris Descartes, Paris, France. Electronic address: claire.carette@aphp.fr. 2. Hôpital Tenon, Service de Biologie de la Reproduction, APHP, Université Pierre et Marie Curie, Paris, France; INSERM UMRS 938, Centre de Recherche Saint-Antoine, Sorbonne Universités, Université Pierre et Marie Curie, IHU ICAN, Paris, France. 3. Hôpital Jean-Verdier, Hôpitaux Universitaires Paris Seine-Saint-Denis, Biologie de la Reproduction, CECOS, APHP, Bondy, France. 4. Centre d'Épidémiologie Clinique, Hôpital Hôtel-Dieu, Paris, France; Team METHODS, Centre of Research in Epidemiology and Statistics Sorbonne, Paris Cité-CRESS Inserm UMR1153, Paris, France; Université Paris Descartes, Paris, France. 5. Service des Explorations Fonctionnelles, Centre Integre Nord Francilien de prise en charge de l'Obesite (CINFO), Hopital Louis Mourier, APHP, Colombes, France. 6. Service de Chirurgie Digestive, Centre Intégré Nord Francilien de prise en charge de l'Obésité (CINFO), Hôpital Louis Mourier, APHP, Colombes, France. 7. Hôpital Avicenne, Hôpitaux Universitaires Paris Seine-Saint-Denis, Service de Chirurgie Générale et Digestive, Centre Intégré Nord Francilien de prise en charge de l'Obésité (CINFO), APHP, Bobigny, France. 8. Hôpital Delafontaine, Centre Hospitalier de Saint-Denis, Chirurgie de l'Obésité, Saint-Denis, France. 9. CHU Clermont Ferrand, Pole Femme Enfants, CECOS, AMP, 1 place Aubrac Clermont Ferrand & IMoST, INSERM 1240, Faculté de médecine, Place Henri Dunand, Clermont Ferrand, France. 10. Centre Hospitalier Universitaire de Clermont-Ferrand, Service de Chirurgie Générale et Digestive, Université Clermont-Auvergne, Clermont-Ferrand, France. 11. Hôpital Européen Georges Pompidou, Service de Nutrition, Centre Spécialisé Obésité (CSO) Ile-de-France Sud, APHP, Université Paris Descartes, Paris, France. 12. Hôpital Européen Georges Pompidou, Service de Chirurgie Digestive, APHP, Université Paris Descartes, Paris, France. 13. Hôpital Ambroise Paré, Service de Nutrition, APHP, Université Versailles Saint Quentin, Boulogne-Billancourt, France. 14. Hôpital Ambroise Paré, Service de Chirurgie Digestive, APHP, Université Versailles Saint Quentin, Boulogne-Billancourt, France. 15. Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), UMR 1329 Oniris-INRA, Nantes, France. 16. Hôpital Européen Georges Pompidou, Service de Nutrition, Centre Spécialisé Obésité (CSO) Ile-de-France Sud, APHP, Université Paris Descartes, Paris, France; Centre d'Épidémiologie Clinique, Hôpital Hôtel-Dieu, Paris, France; Team METHODS, Centre of Research in Epidemiology and Statistics Sorbonne, Paris Cité-CRESS Inserm UMR1153, Paris, France; Université Paris Descartes, Paris, France.
Abstract
BACKGROUND: The massive weight loss induced by bariatric surgery is associated with major benefits, but the effect on semen variables is still uncertain. OBJECTIVES: To explore semen modifications with gastric bypass and sleeve gastrectomy. SETTING: Five French University Hospitals. METHODS: Male candidates for bariatric surgery with no history of infertility were recruited in this controlled prospective study. Sperm characteristics were collected before surgery and then 6 months and up to 12 months after surgery. RESULTS: Forty-six adult men who underwent gastric bypass (n = 20) or sleeve gastrectomy (n = 26) were included. Total sperm count tended to be lower at 6 months and showed a significant decrease at 12 months in both surgery groups, at -69.5 million (-96.8 to -42.2 million; P = 0.0021). Total sperm count at 12 months relative to baseline was -41.4 million (P = .0391) after gastric bypass and -91.1 million (P = .0080) after sleeve gastrectomy. This was counterbalanced by an associated resolution of hypogonadism and decrease of DNA fragmentation in most patients with time after surgery. CONCLUSION: Improvement in some semen variables after bariatric surgery observed in 3 previous studies is in contrast to the lower mean total sperm count found in this study at 1 year. The possible reversibility of this effect in the long term and the impact of surgery on fertility both remain unknown.
BACKGROUND: The massive weight loss induced by bariatric surgery is associated with major benefits, but the effect on semen variables is still uncertain. OBJECTIVES: To explore semen modifications with gastric bypass and sleeve gastrectomy. SETTING: Five French University Hospitals. METHODS: Male candidates for bariatric surgery with no history of infertility were recruited in this controlled prospective study. Sperm characteristics were collected before surgery and then 6 months and up to 12 months after surgery. RESULTS: Forty-six adult men who underwent gastric bypass (n = 20) or sleeve gastrectomy (n = 26) were included. Total sperm count tended to be lower at 6 months and showed a significant decrease at 12 months in both surgery groups, at -69.5 million (-96.8 to -42.2 million; P = 0.0021). Total sperm count at 12 months relative to baseline was -41.4 million (P = .0391) after gastric bypass and -91.1 million (P = .0080) after sleeve gastrectomy. This was counterbalanced by an associated resolution of hypogonadism and decrease of DNA fragmentation in most patients with time after surgery. CONCLUSION: Improvement in some semen variables after bariatric surgery observed in 3 previous studies is in contrast to the lower mean total sperm count found in this study at 1 year. The possible reversibility of this effect in the long term and the impact of surgery on fertility both remain unknown.
Authors: Guilherme Jacom Abdulmassih Wood; Bruno C Tiseo; Davi V Paluello; Hamilton de Martin; Marco Aurelio Santo; William Nahas; Miguel Srougi; Marcello Cocuzza Journal: Obes Surg Date: 2020-07-22 Impact factor: 4.129
Authors: Sana Sultan; Ameet G Patel; Shamsi El-Hassani; Benjamin Whitelaw; Bianca M Leca; Royce P Vincent; Carel W le Roux; Francesco Rubino; Simon J B Aywlin; Georgios K Dimitriadis Journal: Front Endocrinol (Lausanne) Date: 2020-06-19 Impact factor: 5.555