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Literature DB >> 31147199

Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery.

Hugh C Hemmings¹, Paul M Riegelhaupt², Max B Kelz³, Ken Solt⁴, Roderic G Eckenhoff³, Beverley A Orser⁵, Peter A Goldstein⁶.

Abstract

Significant progress has been made in the 21st century towards a comprehensive understanding of the mechanisms of action of general anesthetics, coincident with progress in structural biology and molecular, cellular, and systems neuroscience. This review summarizes important new findings that include target identification through structural determination of anesthetic binding sites, details of receptors and ion channels involved in neurotransmission, and the critical roles of neuronal networks in anesthetic effects on memory and consciousness. These recent developments provide a comprehensive basis for conceptualizing pharmacological control of amnesia, unconsciousness, and immobility.

Entities: Chemical Disease Gene Species

Keywords: consciousness; cortex; hippocampus; hypothalamus; ion channel; memory

Mesh：

Substances：

Year: 2019 PMID： 31147199 PMCID： PMC6830308 DOI： 10.1016/j.tips.2019.05.001

Source DB: PubMed Journal: Trends Pharmacol Sci ISSN： 0165-6147 Impact factor: 14.819

164 in total

1. Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia.

Authors: Norman E Taylor; Christa J Van Dort; Jonathan D Kenny; JunZhu Pei; Jennifer A Guidera; Ksenia Y Vlasov; Justin T Lee; Edward S Boyden; Emery N Brown; Ken Solt
Journal: Proc Natl Acad Sci U S A Date: 2016-10-24 Impact factor: 11.205

2. The common chemical motifs within anesthetic binding sites.

Authors: Edward J Bertaccini; James R Trudell; Nicholas P Franks
Journal: Anesth Analg Date: 2007-02 Impact factor: 5.108

3. Differential effects of deep sedation with propofol on the specific and nonspecific thalamocortical systems: a functional magnetic resonance imaging study.

Authors: Xiaolin Liu; Kathryn K Lauer; B Douglas Ward; Shi-Jiang Li; Anthony G Hudetz
Journal: Anesthesiology Date: 2013-01 Impact factor: 7.892

Review 4. An Emerging Circuit Pharmacology of GABA_A Receptors.

Authors: Elif Engin; Rebecca S Benham; Uwe Rudolph
Journal: Trends Pharmacol Sci Date: 2018-06-11 Impact factor: 14.819

5. Hypnotic hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine β-hydroxylase knockout mice.

Authors: Frances Y Hu; George M Hanna; Wei Han; Feras Mardini; Steven A Thomas; Abraham J Wyner; Max B Kelz
Journal: Anesthesiology Date: 2012-11 Impact factor: 7.892

6. Distinctive recruitment of endogenous sleep-promoting neurons by volatile anesthetics and a nonimmobilizer.

Authors: Bo Han; Hilary S McCarren; Dan O'Neill; Max B Kelz
Journal: Anesthesiology Date: 2014-11 Impact factor: 7.892

Review 7. Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.

Authors: Rebecca J Howard; James R Trudell; R Adron Harris
Journal: Pharmacol Rev Date: 2014-02-10 Impact factor: 25.468

8. Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog.

Authors: Selwyn S Jayakar; William P Dailey; Roderic G Eckenhoff; Jonathan B Cohen
Journal: J Biol Chem Date: 2013-01-08 Impact factor: 5.157

9. Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel.

Authors: Ludovic Sauguet; Zeineb Fourati; Thierry Prangé; Marc Delarue; Nathalie Colloc'h
Journal: PLoS One Date: 2016-02-24 Impact factor: 3.240

10. GABA_A receptor signalling mechanisms revealed by structural pharmacology.

Authors: Simonas Masiulis; Rooma Desai; Tomasz Uchański; Itziar Serna Martin; Duncan Laverty; Dimple Karia; Tomas Malinauskas; Jasenko Zivanov; Els Pardon; Abhay Kotecha; Jan Steyaert; Keith W Miller; A Radu Aricescu
Journal: Nature Date: 2019-01-02 Impact factor: 49.962

52 in total

Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery.

1. Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia.

2. The common chemical motifs within anesthetic binding sites.

3. Differential effects of deep sedation with propofol on the specific and nonspecific thalamocortical systems: a functional magnetic resonance imaging study.

Review 4. An Emerging Circuit Pharmacology of GABA_A Receptors.

5. Hypnotic hypersensitivity to volatile anesthetics and dexmedetomidine in dopamine β-hydroxylase knockout mice.

6. Distinctive recruitment of endogenous sleep-promoting neurons by volatile anesthetics and a nonimmobilizer.

Review 7. Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.

8. Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog.

9. Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel.

10. GABA_A receptor signalling mechanisms revealed by structural pharmacology.

1. Desflurane Anesthesia Alters Cortical Layer-specific Hierarchical Interactions in Rat Cerebral Cortex.

2. Shallow metabolic depression and human spaceflight: a feasible first step.

3. Mechanistic basis of propofol-induced disruption of kinesin processivity.

4. Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics.

5. The brain rhythms that detach us from reality.

Review 6. Serotonin and beyond-a tribute to Manfred Göthert (1939-2019).

7. Differential Effect of Anesthesia on Visual Cortex Neurons with Diverse Population Coupling.

8. D-Amphetamine Rapidly Reverses Dexmedetomidine-Induced Unconsciousness in Rats.

Review 9. Conscious Processing and the Global Neuronal Workspace Hypothesis.

Review 10. Roles of Neuropeptide S in Anesthesia, Analgesia, and Sleep.

Review 4. An Emerging Circuit Pharmacology of GABAA Receptors.

Review 7. Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.

Review 6. Serotonin and beyond-a tribute to Manfred Göthert (1939-2019).

Review 9. Conscious Processing and the Global Neuronal Workspace Hypothesis.

Review 10. Roles of Neuropeptide S in Anesthesia, Analgesia, and Sleep.

Review 4. An Emerging Circuit Pharmacology of GABA_A Receptors.