Literature DB >> 31146182

Development, ontogeny, and maintenance of TCRαβ+ CD8αα IEL.

Roland Ruscher1, Kristin A Hogquist2.   

Abstract

The intestinal epithelium is the outermost cellular layer that separates the body from the gut lumen. The integrity of this protective mucosal barrier is crucial and maintained by specialized cells-intraepithelial lymphocytes (IEL). Much research has been conducted on these cells and our overall understanding of them is increasing rapidly. In this review we focus on the TCRαβ+ subset of CD8αα IEL. We discuss recent studies that shed light on the development, ontogeny, maintenance, and functional characteristics of CD8αα IEL, and highlight yet unanswered questions for future studies.
Copyright © 2019 Elsevier Ltd. All rights reserved.

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Year:  2019        PMID： 31146182      PMCID： PMC6612447          DOI： 10.1016/j.coi.2019.04.010

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  51 in total

1.  T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL.

Authors:  A J Leishman; O V Naidenko; A Attinger; F Koning; C J Lena; Y Xiong; H C Chang; E Reinherz; M Kronenberg; H Cheroutre
Journal:  Science       Date:  2001-11-30       Impact factor: 47.728

Review 2.  The light and dark sides of intestinal intraepithelial lymphocytes.

Authors:  Hilde Cheroutre; Florence Lambolez; Daniel Mucida
Journal:  Nat Rev Immunol       Date:  2011-06-17       Impact factor: 53.106

3.  The checkpoint for agonist selection precedes conventional selection in human thymus.

Authors:  Greet Verstichel; David Vermijlen; Liesbet Martens; Glenn Goetgeluk; Margreet Brouwer; Nicolas Thiault; Yasmine Van Caeneghem; Stijn De Munter; Karin Weening; Sarah Bonte; Georges Leclercq; Tom Taghon; Tessa Kerre; Yvan Saeys; Jo Van Dorpe; Hilde Cheroutre; Bart Vandekerckhove
Journal:  Sci Immunol       Date:  2017-02-24

4.  Krüppel-like factor 2 regulates trafficking and homeostasis of gammadelta T cells.

Authors:  Oludare A Odumade; Michael A Weinreich; Stephen C Jameson; Kristin A Hogquist
Journal:  J Immunol       Date:  2010-04-28       Impact factor: 5.422

5.  Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation.

Authors:  Ying Li; Silvia Innocentin; David R Withers; Natalie A Roberts; Alec R Gallagher; Elena F Grigorieva; Christoph Wilhelm; Marc Veldhoen
Journal:  Cell       Date:  2011-10-13       Impact factor: 41.582

6.  Development of CD8 alpha alpha+ intestinal intraepithelial T cells in beta 2-microglobulin- and/or TAP1-deficient mice.

Authors:  Y Fujiura; M Kawaguchi; Y Kondo; S Obana; H Yamamoto; M Nanno; H Ishikawa
Journal:  J Immunol       Date:  1996-04-15       Impact factor: 5.422

7.  Differential expression of granzyme B and C in murine cytotoxic lymphocytes.

Authors:  Sheng F Cai; Todd A Fehniger; Xuefang Cao; Joshua C Mayer; Joel D Brune; Anthony R French; Timothy J Ley
Journal:  J Immunol       Date:  2009-05-15       Impact factor: 5.422

Review 8.  Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see).

Authors:  Ludger Klein; Bruno Kyewski; Paul M Allen; Kristin A Hogquist
Journal:  Nat Rev Immunol       Date:  2014-05-16       Impact factor: 53.106

9.  Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling.

Authors:  Yan Xing; Xiaodan Wang; Stephen C Jameson; Kristin A Hogquist
Journal:  Nat Immunol       Date:  2016-04-04       Impact factor: 25.606

10.  Hydrophobic CDR3 residues promote the development of self-reactive T cells.

Authors:  Brian D Stadinski; Karthik Shekhar; Iria Gómez-Touriño; Jonathan Jung; Katsuhiro Sasaki; Andrew K Sewell; Mark Peakman; Arup K Chakraborty; Eric S Huseby
Journal:  Nat Immunol       Date:  2016-06-27       Impact factor: 25.606
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  7 in total

Review 1.  The role of the thymus in allogeneic bone marrow transplantation and the recovery of the peripheral T-cell compartment.

Authors:  Enrico Velardi; Emmanuel Clave; Franco Locatelli; Antoine Toubert; Lucas C M Arruda; Francesca Benini
Journal:  Semin Immunopathol       Date:  2021-01-08       Impact factor: 9.623

2.  Bcl-2 Is Necessary to Counteract Bim and Promote Survival of TCRαβ+CD8αα+ Intraepithelial Lymphocyte Precursors in the Thymus.

Authors:  Sharmila Shanmuganad; Sarah A Hummel; Vivian Varghese; David A Hildeman
Journal:  J Immunol       Date:  2022-01-07       Impact factor: 5.422

3.  The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8αα+ intraepithelial lymphocyte precursors.

Authors:  Andrea C Carpenter; Laura B Chopp; Jia Nie; Ting Chen; Mariah Balmaceno-Criss; Thomas Ciucci; Qi Xiao; Michael C Kelly; Dorian B McGavern; Yasmine Belkaid; Rémy Bosselut
Journal:  Nat Immunol       Date:  2022-03-30       Impact factor: 31.250

4.  CD8αα+T cells exert a pro-inflammatory role in patients with psoriasis.

Authors:  Y Y Zhang; Y T Lin; L Wang; X W Sun; E L Dang; K Xue; W G Zhang; K M Zhang; G Wang; B Li
Journal:  Skin Health Dis       Date:  2021-11-16

5.  Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates.

Authors:  Marie-Ève Lebel; Marie Coutelier; Maria Galipeau; Claudia L Kleinman; James J Moon; Heather J Melichar
Journal:  Nat Commun       Date:  2020-07-24       Impact factor: 14.919

Review 6.  Development of Unconventional T Cells Controlled by MicroRNA.

Authors:  Samantha J Winter; Andreas Krueger
Journal:  Front Immunol       Date:  2019-10-23       Impact factor: 7.561

7.  An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.

Authors:  Laura B Chopp; Vishaka Gopalan; Thomas Ciucci; Allison Ruchinskas; Zachary Rae; Manon Lagarde; Yayi Gao; Caiyi Li; Marita Bosticardo; Francesca Pala; Ferenc Livak; Michael C Kelly; Sridhar Hannenhalli; Rémy Bosselut
Journal:  Immunity       Date:  2020-11-25       Impact factor: 31.745
  7 in total

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