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Literature DB >> 31145826

Applying Multiplex Assays to Understand Variation in Pharmacogenes.

Melissa Chiasson¹, Maitreya J Dunham^1,2, Allan E Rettie³, Douglas M Fowler^1,2,4.

Abstract

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Year: 2019 PMID： 31145826 PMCID： PMC6663607 DOI： 10.1002/cpt.1468

Source DB: PubMed Journal: Clin Pharmacol Ther ISSN： 0009-9236 Impact factor: 6.875

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6 in total

Review 1. Clinical and toxicological relevance of CYP2C9: drug-drug interactions and pharmacogenetics.

Authors: Allan E Rettie; Jeffrey P Jones
Journal: Annu Rev Pharmacol Toxicol Date: 2005 Impact factor: 13.820

2. Variant Interpretation: Functional Assays to the Rescue.

Authors: Lea M Starita; Nadav Ahituv; Maitreya J Dunham; Jacob O Kitzman; Frederick P Roth; Georg Seelig; Jay Shendure; Douglas M Fowler
Journal: Am J Hum Genet Date: 2017-09-07 Impact factor: 11.025

3. Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset.

Authors: Adam S Gordon; Holly K Tabor; Andrew D Johnson; Beverly M Snively; Themistocles L Assimes; Paul L Auer; John P A Ioannidis; Ulrike Peters; Jennifer G Robinson; Lara E Sucheston; Danxin Wang; Nona Sotoodehnia; Jerome I Rotter; Bruce M Psaty; Rebecca D Jackson; David M Herrington; Christopher J O'Donnell; Alexander P Reiner; Stephen S Rich; Mark J Rieder; Michael J Bamshad; Deborah A Nickerson
Journal: Hum Mol Genet Date: 2013-11-26 Impact factor: 6.150

4. A cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites.

Authors: Jamil A Haque; Matthew G McDonald; John D Kulman; Allan E Rettie
Journal: Blood Date: 2013-12-02 Impact factor: 22.113

5. Multiplex assessment of protein variant abundance by massively parallel sequencing.

Authors: Kenneth A Matreyek; Lea M Starita; Jason J Stephany; Beth Martin; Melissa A Chiasson; Vanessa E Gray; Martin Kircher; Arineh Khechaduri; Jennifer N Dines; Ronald J Hause; Smita Bhatia; William E Evans; Mary V Relling; Wenjian Yang; Jay Shendure; Douglas M Fowler
Journal: Nat Genet Date: 2018-05-21 Impact factor: 38.330

Review 6. Multiplexed assays of variant effects contribute to a growing genotype-phenotype atlas.

Authors: Jochen Weile; Frederick P Roth
Journal: Hum Genet Date: 2018-08-02 Impact factor: 4.132

6 in total

4 in total

Applying Multiplex Assays to Understand Variation in Pharmacogenes.

Review 1. Clinical and toxicological relevance of CYP2C9: drug-drug interactions and pharmacogenetics.

2. Variant Interpretation: Functional Assays to the Rescue.

3. Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset.

4. A cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites.

5. Multiplex assessment of protein variant abundance by massively parallel sequencing.

Review 6. Multiplexed assays of variant effects contribute to a growing genotype-phenotype atlas.

1. Pharmacogenetics: Chasing Perfection.

2. Transfer learning enables prediction of CYP2D6 haplotype function.

3. Massively parallel characterization of CYP2C9 variant enzyme activity and abundance.

4. CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants.