Lauge Østergaard1, Niels Eske Bruun2,3, Marianne Voldstedlund4, Magnus Arpi5, Christian Østergaard Andersen6, Henrik C Schønheyder7,8, Lars Lemming9, Flemming Rosenvinge10, Nana Valeur11, Peter Søgaard8, Paal Skytt Andersen4,12, Robert Skov4, Ming Chen13, Kasper Iversen14, Sabine Gill15, Trine Kiilerich Lauridsen14, Anders Dahl11,14, Louise Bruun Oestergaard8, Jonas Agerlund Povlsen16, Claus Moser17, Henning Bundgaard1, Lars Køber1, Emil Loldrup Fosbøl1. 1. Department of Cardiology, The Heart Center, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark. 2. Department of Cardiology, Zealand University Hospital, Sygehusvej 10, Roskilde, Denmark. 3. Clinical Institutes, Copenhagen and Aalborg Universities, Søndre Skovvej 15, Aalborg, Denmark. 4. Statens Serum Institut, Artillerivej 5, Copenhagen, Denmark. 5. Department of Clinical Microbiology, Herlev-Gentofte Hospital, Herlev Ringvej 75, Herlev, Denmark. 6. Department of Clinical Microbiology, Amager-Hvidovre Hospital, Kettegård Alle 30, Hvidovre, Denmark. 7. Department of Clinical Microbiology, Aalborg University Hospital, Hobrovej 18, Aalborg, Denmark. 8. Department of Clinical Medicine, Aalborg University, Hobrovej 18, Aalborg, Denmark. 9. Department of Clinical Microbiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus, Denmark. 10. Department of Clinical Microbiology, Odense University Hospital, JB Winsløws vej 21, Odense, Denmark. 11. Department of Cardiology, Bispebjerg Hospital, Bispebjerg bakke 23, Copenhagen, Denmark. 12. Department of Veterinary and Animal Sciences, Faculty of Health and Medical Science, University of Copenhagen, Grønnegårdsvej 15, Frederiksberg, Denmark. 13. Department of Clinical Microbiology, Hospital of Southern Jutland, Sydvang 1, Sønderborg, Denmark. 14. Department of Cardiology, Herlev-Gentofte Hospital, Herlev Ringvej 75, Herlev, Denmark. 15. Department of Cardiology, Odense University Hospital, JB Winsløws vej 4, Odense, Denmark. 16. Department of Cardiology, Palle Juul-Jensens Boulevard 75, Aarhus University Hospital, Aarhus, Denmark. 17. Department of Clinical Microbiology, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.
Abstract
AIMS: Increasing attention has been given to the risk of infective endocarditis (IE) in patients with certain blood stream infections (BSIs). Previous studies have been conducted on selected patient cohorts, yet unselected data are sparse. We aimed to investigate the prevalence of IE in BSIs with bacteria typically associated with IE. METHODS AND RESULTS: By crosslinking nationwide registries from 2010 to 2017, we identified patients with BSIs typically associated with IE: Enterococcus faecalis (E. faecalis), Staphylococcus aureus (S. aureus), Streptococcus spp., and coagulase negative staphylococci (CoNS) and examined the concurrent IE prevalence. A trend test was used to examine temporal changes in the prevalence of IE. In total 69 021, distributed with 15 350, 16 726, 19 251, and 17 694 BSIs were identified in the periods of 2010-2011, 2012-2013, 2014-2015, and 2016-2017, respectively. Patients with E. faecalis had the highest prevalence of IE (16.7%) followed by S. aureus (10.1%), Streptococcus spp. (7.3%), and CoNS (1.6%). Throughout the study period, the prevalence of IE among patients with E. faecalis and Streptococcus spp. increased significantly (P = 0.0005 and P = 0.03, respectively). Male patients had a higher prevalence of IE for E. faecalis, Streptococcus spp., and CoNS compared with females. A significant increase in the prevalence of IE was seen for E. faecalis, Streptococcus spp., and CoNS with increasing age. CONCLUSION: For E. faecalis BSI, 1 in 6 had IE, for S. aureus BSI 1 in 10 had IE, and for Streptococcus spp. 1 in 14 had IE. Our results suggest that screening for IE seems reasonable in patients with E. faecalis BSI, S. aureus BSI, or Streptococcus spp. BSI. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: Increasing attention has been given to the risk of infective endocarditis (IE) in patients with certain blood stream infections (BSIs). Previous studies have been conducted on selected patient cohorts, yet unselected data are sparse. We aimed to investigate the prevalence of IE in BSIs with bacteria typically associated with IE. METHODS AND RESULTS: By crosslinking nationwide registries from 2010 to 2017, we identified patients with BSIs typically associated with IE: Enterococcus faecalis (E. faecalis), Staphylococcus aureus (S. aureus), Streptococcus spp., and coagulase negative staphylococci (CoNS) and examined the concurrent IE prevalence. A trend test was used to examine temporal changes in the prevalence of IE. In total 69 021, distributed with 15 350, 16 726, 19 251, and 17 694 BSIs were identified in the periods of 2010-2011, 2012-2013, 2014-2015, and 2016-2017, respectively. Patients with E. faecalis had the highest prevalence of IE (16.7%) followed by S. aureus (10.1%), Streptococcus spp. (7.3%), and CoNS (1.6%). Throughout the study period, the prevalence of IE among patients with E. faecalis and Streptococcus spp. increased significantly (P = 0.0005 and P = 0.03, respectively). Male patients had a higher prevalence of IE for E. faecalis, Streptococcus spp., and CoNS compared with females. A significant increase in the prevalence of IE was seen for E. faecalis, Streptococcus spp., and CoNS with increasing age. CONCLUSION: For E. faecalis BSI, 1 in 6 had IE, for S. aureus BSI 1 in 10 had IE, and for Streptococcus spp. 1 in 14 had IE. Our results suggest that screening for IE seems reasonable in patients with E. faecalis BSI, S. aureus BSI, or Streptococcus spp. BSI. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: L Wucherpfennig; N Kahn; M R Preusch; M Kriegsmann; C P Heussel; M O Wielpütz; M Kreuter; K Kriegsmann; M Eichinger Journal: Med Klin Intensivmed Notfmed Date: 2020-06-25 Impact factor: 0.840
Authors: Eva Havers-Borgersen; Emil L Fosbøl; Jawad H Butt; Jeppe K Petersen; Andreas Dalsgaard; Frederik Kyhl; Morten Schou; Matthew Phelps; Kristian Kragholm; Gunnar H Gislason; Christian Torp-Pedersen; Lars Køber; Lauge Østergaard Journal: Int J Cardiol Heart Vasc Date: 2020-11-06
Authors: Sandra Chamat-Hedemand; Niels Eske Bruun; Lauge Østergaard; Magnus Arpi; Emil Fosbøl; Jonas Boel; Louise Bruun Oestergaard; Trine K Lauridsen; Gunnar Gislason; Christian Torp-Pedersen; Anders Dahl Journal: BMC Infect Dis Date: 2021-07-16 Impact factor: 3.090