Literature DB >> 31143456

May your drug price be evergreen.

Robin Feldman1.   

Abstract

Presenting the first comprehensive study of evergreening, this article examines the extent to which evergreening behavior-which can be defined as artificially extending the protection cliff-may contribute to the problem. The author analyses all drugs on the market between 2005 and 2015, combing through 60,000 data points to examine every instance in which a company added a new patent or exclusivity. The results show a startling departure from the classic conceptualization of intellectual property protection for pharmaceuticals. Rather than creating new medicines, pharmaceutical companies are largely recycling and repurposing old ones. Specifically, 78% of the drugs associated with new patents were not new drugs, but existing ones, and extending protection is particularly pronounced among blockbuster drugs. Once companies start down the road of extending protection, they show a tendency to return to the well, with the majority adding more than one extension and 50% becoming serial offenders. The problem is growing across time.

Entities:  

Keywords:  Drugs; Evergreening; Patents; Pharmaceuticals; Pricing

Year:  2018        PMID: 31143456      PMCID: PMC6534750          DOI: 10.1093/jlb/lsy022

Source DB:  PubMed          Journal:  J Law Biosci        ISSN: 2053-9711


  7 in total

Review 1.  Pharmaceutical drug development: high drug prices and the hidden role of public funding.

Authors:  Stephanie Annett
Journal:  Biol Futur       Date:  2020-06-22

2.  Evergreening of Psychiatric Medications: A Systemic Literature Review of Strategies, Case Examples, and the Implications of Cost.

Authors:  Joy K L Andrade; Cierra J Fujimoto; Earl S Hishinuma; Isa A Miyamoto; Jame A Agapoff; Stacy L Kracher; Junji Takeshita; Carol O China
Journal:  Community Ment Health J       Date:  2022-09-12

Review 3.  100 years of Insulin: Why is Insulin So Expensive and What Can be Done to Control Its Cost?

Authors:  William H Herman; Shihchen Kuo
Journal:  Endocrinol Metab Clin North Am       Date:  2021-10-14       Impact factor: 4.748

Review 4.  What is the impact of intellectual property rules on access to medicines? A systematic review.

Authors:  Brigitte Tenni; Hazel V J Moir; Belinda Townsend; Burcu Kilic; Anne-Maree Farrell; Tessa Keegel; Deborah Gleeson
Journal:  Global Health       Date:  2022-04-15       Impact factor: 10.401

5.  Approvals and Timing of New Formulations of Novel Drugs Approved by the US Food and Drug Administration Between 1995 and 2010 and Followed Through 2021.

Authors:  Ravi Gupta; Christopher J Morten; Angela Y Zhu; Reshma Ramachandran; Nilay D Shah; Joseph S Ross
Journal:  JAMA Health Forum       Date:  2022-05-20

6.  21st-century capitalism: structural challenges for universal health care.

Authors:  Susan K Sell
Journal:  Global Health       Date:  2019-11-28       Impact factor: 4.185

7.  The fall of the innovation empire and its possible rise through open science.

Authors:  E Richard Gold
Journal:  Res Policy       Date:  2021-06
  7 in total

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