Literature DB >> 3114192

Selective induction of glandular stomach carcinoma in F344 rats by N-methyl-N-nitrosourea.

N Hirota, T Aonuma, S Yamada, T Kawai, K Saito, T Yokoyama.   

Abstract

To study the carcinogenic action of N-methyl-N-nitrosourea (MNU) on the stomach, MNU in distilled water at a concentration of 400 ppm was provided as drinking water to F344 male rats for 25 weeks (group I) or 15 weeks (group II). Twenty weeks following the cessation of the administration, invasive adenocarcinomas were found in the glandular stomach in 100% of 16 rats in group I and 38% of 21 rats in group II. Bone formation occurred within the stroma of carcinoma in 5 rats in group I. No neoplastic lesions developed in the esophagus, forestomach or duodenum of any rat. Thus, MNU in drinking water selectively induces glandular stomach carcinoma in high incidence in these rats.

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Year:  1987        PMID： 3114192

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  9 in total

1.  DNA methylation in the digestive tract of F344 rats during chronic exposure to N-methyl-N-nitrosourea.

Authors:  H Ohgaki; B I Ludeke; I Meier; P Kleihues; W K Lutz; C Schlatter
Journal:  J Cancer Res Clin Oncol       Date:  1991       Impact factor: 4.553

2.  Dose-dependent induction of both pepsinogen-altered pyloric glands and adenocarcinomas in the glandular stomach of C3H mice treated with N-methyl-N-nitrosourea.

Authors:  M Yamamoto; C Furihata; Y Fujimitsu; T Imai; K Inada; H Nakanishi; M Tatematsu
Journal:  Jpn J Cancer Res       Date:  1997-03

3.  Enhancing potential of 6 different carcinogens on multi-organ tumorigenesis after initial treatment with N-methyl-N-nitrosourea in rats.

Authors:  S Uwagawa; H Tsuda; T Inoue; Y Tagawa; T Aoki; M Kagawa; T Ogiso; N Ito
Journal:  Jpn J Cancer Res       Date:  1991-12

4.  Induction of glandular stomach cancers in Helicobacter pylori-sensitive Mongolian gerbils treated with N-methyl-N-nitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine in drinking water.

Authors:  M Tatematsu; M Yamamoto; N Shimizu; A Yoshikawa; H Fukami; M Kaminishi; T Oohara; A Sugiyama; T Ikeno
Journal:  Jpn J Cancer Res       Date:  1998-02

5.  Antioxidant and immunity activities of Fufang Kushen Injection Liquid.

Authors:  Shen-Kang Zhou; Rui-Li Zhang; Yun-Feng Xu; Tie-Nan Bi
Journal:  Molecules       Date:  2012-05-30       Impact factor: 4.411

6.  Induction of glandular stomach cancers in C3H mice treated with N-methyl-N-nitrosourea in the drinking water.

Authors:  M Tatematsu; M Yamamoto; H Iwata; H Fukami; H Yuasa; N Tezuka; T Masui; H Nakanishi
Journal:  Jpn J Cancer Res       Date:  1993-12

7.  Elevated serum growth hormone accelerates gastric tumorigenesis in F344 rats after treatment with N-methyl-N-nitrosourea in their drinking water.

Authors:  H Watanabe; N Fujimoto; K Kawamoto; Y Ando; K Yamada; T Okamoto; G N Kanin; A Ito
Journal:  Jpn J Cancer Res       Date:  1995-07

8.  Lack of any positive effect of intestinal metaplasia on induction of gastric tumors in Wistar rats treated with N-methyl-N-nitrosourea in their drinking water.

Authors:  H Watanabe; Y Ando; K Yamada; T Okamoto; A Ito
Journal:  Jpn J Cancer Res       Date:  1994-09

9.  Carcinogenesis by nitrosohydroxyethylurea and nitrosomethoxyethylurea in F344 rats.

Authors:  W Lijinsky; R M Kovatch
Journal:  Jpn J Cancer Res       Date:  1988-02
  9 in total

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