| Literature DB >> 31140965 |
Ainal Mardziah Che Hamzah1, Chew Chieng Yeo2, Suat Moi Puah3, Kek Heng Chua3, Nor Iza A Rahman2, Fatimah Haslina Abdullah4, Norlela Othman4, Ching Hoong Chew1.
Abstract
The spread of multidrug-resistant Staphylococcus aureus is a public health concern. The inducible macrolide-lincosamide-streptogrammin B (iMLSB ) phenotype (or inducible clindamycin resistance) is associated with false clindamycin susceptibility in routine laboratory testing and may lead to treatment failure. Tigecycline resistance remains rare in S. aureus worldwide. This study aims to determine the antimicrobial susceptibility profiles of clinical isolates of S. aureus obtained from the main tertiary hospital in Terengganu state, Malaysia, from July 2016 to June 2017. The antimicrobial susceptibilities of 90 methicillin-resistant S. aureus (MRSA) and 109 methicillin-susceptible S. aureus (MSSA) isolates were determined by disc diffusion with the iMLSB phenotype determined by D-test. Multidrug resistance (MDR) and the iMLSB phenotype were more prevalent in MRSA (84.4 and 46.7 %, respectively) compared to MSSA isolates. All five tigecycline-resistant isolates were MRSA. The high incidence of MDR and the iMLSB phenotype and the emergence of tigecycline resistance in the Terengganu S. aureus isolates warrants continuous vigilance.Entities:
Keywords: inducible clindamycin resistance; methicillin-resistant S. aureus; methicillin-susceptible S. aureus; multidrug resistance; tigecycline resistance
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Year: 2019 PMID： 31140965 DOI： 10.1099/jmm.0.000993
Source DB: PubMed Journal: J Med Microbiol ISSN： 0022-2615 Impact factor: 2.472