Hao Xing1, Haibo Qiu2, Xuemei Ding2, Jun Han1, Zhenli Li1, Han Wu1, Cunling Yan3, Huijun Li4, Ruilin Han3, Han Zhang1, Chao Li1, Mingda Wang1, Mengchao Wu1, Feng Shen1, Yijie Zheng5, Tian Yang1. 1. Department of Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, PR China. 2. Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, PR China. 3. Department of Clinical Laboratory, Peking University First Hospital, Beijing, PR China. 4. Department of Laboratory Medicine, Huazhong University of Science and Technology, Tongji Medical College, Tongji Hospital, Wuhan, PR China. 5. Medical Scientific Affairs, Abbott Diagnostics, Shanghai, PR China.
Abstract
Aim: To evaluate the diagnostic performance of serum AFU for early stage hepatocellular carcinoma (HCC). Methods: Concentration of AFU and AFP were measured in 512 patients. The performance was compared for AFU and AFP alone or in combination. Results: The area under the curve (AUC) for AFU was 0.68, with a sensitivity of 56.1% and specificity of 69.2% at the cut-off value of 24 U/l; whereas the AUC for AFP was 0.83, with a sensitivity of 58.2% and specificity of 85.2% at cut-off value of 20 ng/ml. The AUC of AFU alone or the combination with AFP were lower than that of AFP alone. Conclusion: AFU is a suboptimal biomarker for early detection of HCC.
Aim: To evaluate the diagnostic performance of serum AFU for early stage hepatocellular carcinoma (HCC). Methods: Concentration of AFU and AFP were measured in 512 patients. The performance was compared for AFU and AFP alone or in combination. Results: The area under the curve (AUC) for AFU was 0.68, with a sensitivity of 56.1% and specificity of 69.2% at the cut-off value of 24 U/l; whereas the AUC for AFP was 0.83, with a sensitivity of 58.2% and specificity of 85.2% at cut-off value of 20 ng/ml. The AUC of AFU alone or the combination with AFP were lower than that of AFP alone. Conclusion:AFU is a suboptimal biomarker for early detection of HCC.
Entities:
Keywords:
area under the curve; biomarker; diagnostic performance; early detection; early stage-HCC; hepatocellular carcinoma; sensitivity; specificity; α-L-fucosidase; α-fetoprotein
Authors: Neehar D Parikh; Anand S Mehta; Amit G Singal; Timothy Block; Jorge A Marrero; Anna S Lok Journal: Cancer Epidemiol Biomarkers Prev Date: 2020-04-01 Impact factor: 4.254