Zhengxiang Ji1, Qi Fang1, Liqiang Yu1. 1. Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Abstract
OBJECTIVE: To investigate the relationship between Toll-like receptor 4 (TLR4) and collateral circulation in patients with acute cerebral infarction (AIS) after thrombolytic therapy. METHODS: This retrospective, observational cohort study was conducted among 65 patients with AIS receiving thrombolytic therapy, who were divided according to findings by computed tomographic angiography (CTA) into good collateral circulation (group A, n = 34) and poor collateral circulation (group B, n = 31). Serum samples were collected from all the patients and the levels of TLR4 were measured with ELISA. RESULTS: The patients in group A had significantly better outcomes than those in group B. The NIHSS scores at 24 h and 30 days after thrombolytic therapy, mRS scores at 90 days and serum TLR4 levels were significantly lower in group A than in group B (P < 0.05); the percentages of patients with symptomatic intracerebral hemorrhage were comparable between the two groups. The serum levels of TLR4 were negatively correlated with the rMLC score (P < 0.05). Multivariate logistic regression analysis showed that a high level of TLR4 was associated with a poor collateral circulation after thrombolysis. CONCLUSIONS: Good collateral circulation can increase the benefit of intravenous thrombolysis in patients with ACI, and the level of TLR4 is a predictive factor for the compensation of collateral circulation following ACI.
OBJECTIVE: To investigate the relationship between Toll-like receptor 4 (TLR4) and collateral circulation in patients with acute cerebral infarction (AIS) after thrombolytic therapy. METHODS: This retrospective, observational cohort study was conducted among 65 patients with AIS receiving thrombolytic therapy, who were divided according to findings by computed tomographic angiography (CTA) into good collateral circulation (group A, n = 34) and poor collateral circulation (group B, n = 31). Serum samples were collected from all the patients and the levels of TLR4 were measured with ELISA. RESULTS: The patients in group A had significantly better outcomes than those in group B. The NIHSS scores at 24 h and 30 days after thrombolytic therapy, mRS scores at 90 days and serum TLR4 levels were significantly lower in group A than in group B (P &lt; 0.05); the percentages of patients with symptomatic intracerebral hemorrhage were comparable between the two groups. The serum levels of TLR4 were negatively correlated with the rMLC score (P &lt; 0.05). Multivariate logistic regression analysis showed that a high level of TLR4 was associated with a poor collateral circulation after thrombolysis. CONCLUSIONS: Good collateral circulation can increase the benefit of intravenous thrombolysis in patients with ACI, and the level of TLR4 is a predictive factor for the compensation of collateral circulation following ACI.
Authors: Alexander Y L Lau; Edward H C Wong; Adrian Wong; Vincent C T Mok; Thomas W Leung; Ka-sing Lawrence Wong Journal: Cerebrovasc Dis Date: 2012-04-25 Impact factor: 2.762
Authors: Sònia Abilleira; Aida Ribera; Pedro Cardona; Marta Rubiera; Elena López-Cancio; Sergi Amaro; Ana Rodríguez-Campello; Pol Camps-Renom; David Cánovas; Maria Angels de Miquel; Alejandro Tomasello; Sebastian Remollo; Antonio López-Rueda; Elio Vivas; Joan Perendreu; Miquel Gallofré Journal: Stroke Date: 2017-01-06 Impact factor: 7.914
Authors: Bijoy K Menon; Emmad Qazi; Vivek Nambiar; Lydia D Foster; Sharon D Yeatts; David Liebeskind; Tudor G Jovin; Mayank Goyal; Michael D Hill; Thomas A Tomsick; Joseph P Broderick; Andrew M Demchuk Journal: Stroke Date: 2015-03-19 Impact factor: 7.914